{"id":"W2164604582","doi":"10.1085/jgp.201311045","title":"Peregrination of the selectivity filter delineates the pore of the human voltage-gated proton channel hHV1","year":2013,"lang":"en","type":"article","venue":"The Journal of General Physiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Selectivity; Chemistry; KcsA potassium channel; Biophysics; Gating; Ion channel; Proton; Molecular dynamics; Helix (gastropod); Potassium channel; Thermal conduction; Transmembrane protein; Permeation; Membrane; Stereochemistry; Materials science; Biochemistry; Computational chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003477441,0.00009804495,0.0001375134,0.00002072581,0.0001721643,0.000005448161,0.0003522075,0.00009162988,0.00003641915],"category_scores_gemma":[0.0000682227,0.00003727827,0.0001564483,0.0001127162,0.0002034495,0.000008321663,0.0001019629,0.0001644709,8.380192e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001079456,"about_ca_system_score_gemma":0.00004425461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000723894,"about_ca_topic_score_gemma":0.00001209355,"domain_scores_codex":[0.9990315,0.0003488047,0.0002895865,0.00007988736,0.0001365916,0.0001136296],"domain_scores_gemma":[0.9986773,0.00002108187,0.0005223032,0.0002662678,0.000496542,0.00001646771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006667339,0.00004211751,0.0003002246,0.0000097122,0.00005002837,1.955065e-8,0.0001362436,0.003749767,0.992425,0.00004540955,0.002926583,0.0002482627],"study_design_scores_gemma":[0.000346625,0.0003040982,0.08384542,0.00001341136,0.00003187441,0.00002108012,0.0001051876,0.002098232,0.9109862,0.001330056,0.0008616748,0.00005615912],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975293,0.00008576691,0.000277188,0.001353849,0.0003263801,0.0003580607,0.000003631081,0.000001541539,0.0000642655],"genre_scores_gemma":[0.9983141,0.00002671852,0.000008010253,0.000271866,0.0005786663,0.000008303529,0.000008803168,0.000008452351,0.0007750532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08354519,"threshold_uncertainty_score":0.1520164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01264398269875497,"score_gpt":0.2397372943963738,"score_spread":0.2270933116976189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}