{"id":"W2164642954","doi":"10.1002/ajmg.a.20495","title":"The hedgehog signaling network","year":2003,"lang":"en","type":"review","venue":"American Journal of Medical Genetics Part A","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":413,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Patched; Smoothened; Hedgehog; Biology; Cell biology; Hedgehog signaling pathway; Transmembrane protein; Signal transduction; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002321067,0.0006891244,0.0003705376,0.0006091244,0.0006340098,0.002331286,0.0005747982,0.0006824154,0.02340335],"category_scores_gemma":[0.0003811298,0.0001925511,0.0002539626,0.0005418226,0.0005964467,0.0009276497,0.00170298,0.0007736001,0.01046619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001037467,"about_ca_system_score_gemma":0.001386452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001463805,"about_ca_topic_score_gemma":0.001398698,"domain_scores_codex":[0.9996465,0.00004410972,0.00001921555,0.00009450292,0.0001289891,0.00006676961],"domain_scores_gemma":[0.9998174,0.00001576537,0.00002344358,0.00002330157,0.00005527684,0.00006477771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003094769,0.00009407994,0.004297545,0.001104216,0.0001746918,0.001141219,0.0003824783,0.001846169,0.04213084,0.1809097,0.1451458,0.6224637],"study_design_scores_gemma":[0.00003357812,0.00008764978,0.002904299,0.0002543628,0.00005195678,0.0009173095,0.0001483958,0.0008404634,0.004699026,0.03048872,0.9595521,0.00002207062],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"review","genre_scores_codex":[0.05171622,0.09259713,0.04281954,0.01319404,0.00365326,0.0004698767,0.009355934,0.002694016,0.7835],"genre_scores_gemma":[0.5411307,0.06609913,0.02714297,0.008399303,0.001356064,0.0004707423,0.01159637,0.0002291362,0.3435756],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.02340335,"threshold_uncertainty_score":0.07829201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03721702758325577,"score_gpt":0.3484946675660194,"score_spread":0.3112776399827636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}