{"id":"W2164670208","doi":"10.1002/9783527683031.ch1","title":"Global Approaches to Understanding Protein Kinase Functions","year":2015,"lang":"en","type":"other","venue":"","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"","keywords":"Kinase; Function (biology); Gene knockdown; Computational biology; Protein kinase A; Biology; Cell biology; ASK1; RNA interference; Disease; Mitogen-activated protein kinase kinase; Genetics; Medicine; Cell culture; Gene; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005073732,0.001321337,0.0009411092,0.001019147,0.000589313,0.001330587,0.001091045,0.0006557279,0.003962052],"category_scores_gemma":[0.0004481915,0.0005199423,0.0008072447,0.0009280806,0.001372325,0.002714905,0.001415174,0.002789727,0.001543777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001314477,"about_ca_system_score_gemma":0.0006964981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001330788,"about_ca_topic_score_gemma":0.001849719,"domain_scores_codex":[0.999782,0.00002414438,0.0000131281,0.0001111995,0.00004164492,0.00002792409],"domain_scores_gemma":[0.9998811,0.0000272451,0.00002108772,0.00004107552,0.00001577507,0.00001369587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002157001,0.00008778468,0.001943405,0.001067175,0.0001394573,0.0001670442,0.000291827,0.02203173,0.5064045,0.3258634,0.003598394,0.1381897],"study_design_scores_gemma":[0.00007467005,0.0003248268,0.01306945,0.0002137068,0.0002873297,0.001040102,0.0006368691,0.06425291,0.270342,0.3546157,0.2950166,0.0001259377],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"other","genre_scores_codex":[0.07625318,0.02406774,0.8344253,0.001642744,0.0003704733,0.0001480813,0.002380726,0.002889778,0.0578219],"genre_scores_gemma":[0.5023884,0.05016503,0.4182447,0.001239938,0.0003092544,0.0008687311,0.004612606,0.001106482,0.02106491],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.003962052,"threshold_uncertainty_score":0.01325434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1476762751574112,"score_gpt":0.2495025798191389,"score_spread":0.1018263046617277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}