{"id":"W2164673602","doi":"10.1158/1055-9965.epi-09-0363","title":"Cyclooxygenase-2 Polymorphisms, Aspirin Treatment, and Risk for Colorectal Adenoma Recurrence—Data from a Randomized Clinical Trial","year":2009,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Public Health Ontario; University of Toronto; Sunnybrook Health Science Centre","funders":"National Cancer Institute; National Institutes of Health","keywords":"Aspirin; Colorectal adenoma; Medicine; Internal medicine; Colorectal cancer; Relative risk; Gastroenterology; Adenoma; Single-nucleotide polymorphism; Minor allele frequency; Placebo; Cyclooxygenase; Randomized controlled trial; Proportional hazards model; Oncology; Confidence interval; Cancer; Pathology; Genotype; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004254977,0.000958227,0.003472997,0.0004052111,0.0004682928,0.001215106,0.0008114946,0.002197937,0.007448891],"category_scores_gemma":[0.007093825,0.000473233,0.004320208,0.0007223034,0.0007443087,0.0008771498,0.0003563024,0.002296959,0.0005886895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004451989,"about_ca_system_score_gemma":0.0008000455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009791366,"about_ca_topic_score_gemma":0.001977827,"domain_scores_codex":[0.9971043,0.001911373,0.0003169558,0.0003252514,0.0002057626,0.0001362611],"domain_scores_gemma":[0.9949188,0.002579229,0.001243454,0.0004399195,0.0003023257,0.0005162508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9722015,0.0007378446,0.003209739,0.002104842,0.01206473,0.00005980426,0.0000275164,0.0002801247,0.0007424686,0.0001032457,0.001009108,0.007459008],"study_design_scores_gemma":[0.9463739,0.01823002,0.01449254,0.0002764321,0.01737103,0.00009486065,0.00002685097,0.0007243809,0.0002761201,0.0004145845,0.001679772,0.00003937067],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9217371,0.06132805,0.001558833,0.002543336,0.001651696,0.002488717,0.004995484,0.0001090304,0.00358773],"genre_scores_gemma":[0.9782045,0.009635279,0.001360742,0.00196581,0.0007803973,0.002635349,0.003160151,0.00002887282,0.002228978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007448891,"threshold_uncertainty_score":0.02491897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1356094444407503,"score_gpt":0.4458268165072908,"score_spread":0.3102173720665405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}