{"id":"W2164673602","doi":"10.1158/1055-9965.epi-09-0363","title":"Cyclooxygenase-2 Polymorphisms, Aspirin Treatment, and Risk for Colorectal Adenoma Recurrence—Data from a Randomized Clinical Trial","year":2009,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Public Health Ontario; University of Toronto; Sunnybrook Health Science Centre","funders":"National Cancer Institute; National Institutes of Health","keywords":"Aspirin; Colorectal adenoma; Medicine; Internal medicine; Colorectal cancer; Relative risk; Gastroenterology; Adenoma; Single-nucleotide polymorphism; Minor allele frequency; Placebo; Cyclooxygenase; Randomized controlled trial; Proportional hazards model; Oncology; Confidence interval; Cancer; Pathology; Genotype; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.008780105,0.0003563924,0.002034862,0.0001226953,0.0001588816,0.000009860159,0.0001785021,0.0005307374,0.0001028802],"category_scores_gemma":[0.006846888,0.0002678347,0.0005909528,0.0001036347,0.000435495,0.0001298581,0.00004871508,0.0002363219,0.00001450032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001588112,"about_ca_system_score_gemma":0.0003395682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005608025,"about_ca_topic_score_gemma":0.0002600042,"domain_scores_codex":[0.9933482,0.003614021,0.001435446,0.001018564,0.0000916036,0.0004921894],"domain_scores_gemma":[0.9912553,0.006799316,0.000924684,0.0006180253,0.00006547246,0.0003371623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.646767,0.0003424084,0.08825696,0.0000226931,0.001817596,0.00001069442,0.00004525507,3.809281e-7,0.0001989537,0.00005570233,0.008263527,0.2542188],"study_design_scores_gemma":[0.7922933,0.006362092,0.1756737,0.0003695365,0.004252725,0.00001678881,0.00002019695,0.005686891,0.0002606368,0.008152102,0.0064987,0.0004133687],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9637597,0.02352712,0.002857581,0.001923107,0.002367494,0.00505604,0.000375054,0.00008618091,0.00004777816],"genre_scores_gemma":[0.9401776,0.03449389,0.01108249,0.001111648,0.005732261,0.001993121,0.004919427,0.00006619567,0.0004233345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2538055,"threshold_uncertainty_score":0.9999774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1356094444407503,"score_gpt":0.4458268165072908,"score_spread":0.3102173720665405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}