{"id":"W2164726383","doi":"10.1128/mcb.25.3.1135-1145.2005","title":"Muscle-Specific Pten Deletion Protects against Insulin Resistance and Diabetes","year":2005,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":236,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Toronto; Ontario Institute for Cancer Research; Hospital for Sick Children","funders":"","keywords":"PTEN; Tensin; Insulin resistance; Biology; Endocrinology; Internal medicine; Protein kinase B; PI3K/AKT/mTOR pathway; Hyperinsulinemia; Phosphatase; Glucose uptake; Insulin receptor; Insulin; Glucose homeostasis; Phosphoinositide 3-kinase; GLUT4; Phosphorylation; Cell biology; Signal transduction; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002327674,0.0002409713,0.000211969,0.00006024519,0.0001146569,0.00003168226,0.0001522448,0.0003146197,0.00001268758],"category_scores_gemma":[0.00004290991,0.0002373344,0.00006760764,0.00008530125,0.0002394626,0.00000516909,0.0001316469,0.0001485415,0.000008121476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001937934,"about_ca_system_score_gemma":0.00003063901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003052164,"about_ca_topic_score_gemma":0.00001326081,"domain_scores_codex":[0.9985255,0.0001452492,0.0002349276,0.0006342043,0.0000838086,0.0003762874],"domain_scores_gemma":[0.9993636,0.00001187311,0.0000894129,0.0003527633,0.00006694676,0.000115389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005188365,0.00002779047,0.0004642498,0.00002483493,0.00003724339,0.000006930488,0.00002359996,0.0000169959,0.9747174,0.0002893963,0.0002583251,0.02408132],"study_design_scores_gemma":[0.0006063352,0.0001934457,0.0003298846,0.00002024828,0.00001078079,0.000002989603,0.00001122055,0.00007816903,0.7577348,0.0002410212,0.2404857,0.0002855048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9539679,0.03870157,0.005806181,0.0003760782,0.00009034383,0.0002757286,0.00001973715,0.00002616882,0.000736281],"genre_scores_gemma":[0.9956937,0.001115824,0.001720407,0.0007486438,0.0002659547,0.00006550309,0.0001882528,0.0000363101,0.0001654296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2402273,"threshold_uncertainty_score":0.9678216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005818595323303355,"score_gpt":0.2045353716864884,"score_spread":0.198716776363185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}