{"id":"W2164726383","doi":"10.1128/mcb.25.3.1135-1145.2005","title":"Muscle-Specific Pten Deletion Protects against Insulin Resistance and Diabetes","year":2005,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":236,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Toronto; Ontario Institute for Cancer Research; Hospital for Sick Children","funders":"","keywords":"PTEN; Tensin; Insulin resistance; Biology; Endocrinology; Internal medicine; Protein kinase B; PI3K/AKT/mTOR pathway; Hyperinsulinemia; Phosphatase; Glucose uptake; Insulin receptor; Insulin; Glucose homeostasis; Phosphoinositide 3-kinase; GLUT4; Phosphorylation; Cell biology; Signal transduction; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001954901,0.0007379368,0.0005223956,0.0006594544,0.000205836,0.0003328822,0.0003753475,0.0004608909,0.001771514],"category_scores_gemma":[0.0001392855,0.0002893834,0.000298038,0.0002891882,0.0003711589,0.0002741607,0.0002901949,0.0009124664,0.0004234783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001922209,"about_ca_system_score_gemma":0.0002633109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003662856,"about_ca_topic_score_gemma":0.0005024481,"domain_scores_codex":[0.9998202,0.00002126209,0.00001946687,0.00004229291,0.00004205345,0.00005474962],"domain_scores_gemma":[0.9997531,0.00002090881,0.00008689749,0.00002264601,0.00001595724,0.000100519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005983524,0.0001694701,0.0002618869,0.00003650669,0.00002270469,0.00009515447,0.00001105659,0.0001143591,0.9957584,0.0001860766,0.00009987349,0.002646161],"study_design_scores_gemma":[0.0002982068,0.004228517,0.01180088,0.00002988067,0.0001380034,0.0008557715,0.00005222655,0.001406455,0.9761162,0.0002928134,0.004759374,0.00002166433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993839,0.001134389,0.002090174,0.0001920505,0.00006955988,0.00004092874,0.0004786198,0.0003289543,0.001826387],"genre_scores_gemma":[0.9914697,0.001263173,0.001338348,0.0001503524,0.0000286529,0.00005250791,0.001040303,0.00006471581,0.004592385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001771514,"threshold_uncertainty_score":0.005926311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005818595323303355,"score_gpt":0.2045353716864884,"score_spread":0.198716776363185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}