{"id":"W2164735291","doi":"10.1074/mcp.m112.020164","title":"Driving Forces of Proteasome-catalyzed Peptide Splicing in Yeast and Humans","year":2012,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Università di Bologna; University of Toronto; Deutsche Forschungsgemeinschaft; Imperial College London","keywords":"Yeast; RNA splicing; Chemistry; Proteasome; Cell biology; Saccharomyces cerevisiae; Peptide; Biochemistry; Biology; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003035027,0.0003397901,0.0002375555,0.000192548,0.0002038944,0.0005907146,0.000266929,0.0003735897,0.000525573],"category_scores_gemma":[0.0003247345,0.0002414056,0.0002471101,0.0001662777,0.0003595111,0.0003055193,0.0002690661,0.0002851482,0.0003756126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000508479,"about_ca_system_score_gemma":0.0002548166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007349821,"about_ca_topic_score_gemma":0.0004699411,"domain_scores_codex":[0.9997955,0.00002800103,0.00001355693,0.00008402965,0.00004942968,0.00002938829],"domain_scores_gemma":[0.9998868,0.00001986994,0.0000400679,0.00001434001,0.00001275015,0.00002618079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003734412,0.0000408915,0.006807158,0.0001631862,0.0000291812,0.00062027,0.0002168754,0.004113359,0.9382208,0.02296804,0.0003269507,0.02611977],"study_design_scores_gemma":[0.00007692181,0.0006865434,0.03525805,0.00004247082,0.00007028152,0.002502034,0.0003567995,0.02482265,0.894101,0.01573095,0.02627932,0.00007295316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.976836,0.003752711,0.01543627,0.0002277482,0.00002417478,0.00001865195,0.0002282853,0.0002764305,0.003199787],"genre_scores_gemma":[0.9916562,0.0009351578,0.006539199,0.00005048347,0.000008025373,0.00001257421,0.0001910461,0.00002143521,0.0005859545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007349821,"threshold_uncertainty_score":0.003689229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009254649309494746,"score_gpt":0.2245803680128036,"score_spread":0.2153257187033088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}