{"id":"W2164735291","doi":"10.1074/mcp.m112.020164","title":"Driving Forces of Proteasome-catalyzed Peptide Splicing in Yeast and Humans","year":2012,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Università di Bologna; University of Toronto; Deutsche Forschungsgemeinschaft; Imperial College London","keywords":"Yeast; RNA splicing; Chemistry; Proteasome; Cell biology; Saccharomyces cerevisiae; Peptide; Biochemistry; Biology; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005702035,0.0002514159,0.0002767583,0.000110554,0.00006687655,0.00002557354,0.0002167424,0.0002035118,0.00001227844],"category_scores_gemma":[0.0001071239,0.0002653692,0.0001077255,0.0001336527,0.000118864,0.00001585106,0.0002500401,0.0001801559,0.000006195862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002097552,"about_ca_system_score_gemma":0.00004904207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005360949,"about_ca_topic_score_gemma":0.00002122772,"domain_scores_codex":[0.9984739,0.0001214386,0.0003649654,0.0003679656,0.0001792091,0.0004925053],"domain_scores_gemma":[0.9991909,0.000006800571,0.0001719057,0.0004322881,0.00005005042,0.0001480175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003646389,0.00007957628,0.02560088,0.0001124412,0.00002947454,0.00000584075,0.0002931975,0.00002581821,0.97291,0.0004489033,0.000006218269,0.0004511984],"study_design_scores_gemma":[0.0006228639,0.00009562316,0.002579998,0.00008226065,0.00001978678,0.00001551552,0.0001137213,0.00009227441,0.9952256,0.0001554032,0.0007018219,0.0002951028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896687,0.001606664,0.006722784,0.0000309316,0.0000545174,0.001067537,0.00001103689,0.00001463679,0.0008231833],"genre_scores_gemma":[0.9926218,0.00005418566,0.006753309,0.00004972193,0.0001193813,0.0001465229,0.00007121464,0.00005579117,0.0001280612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02302088,"threshold_uncertainty_score":0.9999799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009254649309494746,"score_gpt":0.2245803680128036,"score_spread":0.2153257187033088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}