{"id":"W2164744416","doi":"10.4049/jimmunol.171.2.538","title":"Cutting Edge: The Conversion of Arginine to Citrulline Allows for a High-Affinity Peptide Interaction with the Rheumatoid Arthritis-Associated HLA-DRB1*0401 MHC Class II Molecule","year":2003,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":707,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Western University","funders":"","keywords":"Citrulline; Citrullination; Epitope; Arginine; Major histocompatibility complex; Chemistry; MHC class I; Peptide; MHC class II; Human leukocyte antigen; Autoimmunity; Rheumatoid arthritis; Immunology; Antigen; Biology; Immune system; Biochemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001977003,0.0001634629,0.0004600694,0.0001113295,0.0004589226,0.00001211581,0.0003335775,0.00008447072,0.0001281687],"category_scores_gemma":[0.0008844998,0.00007172017,0.0001527581,0.0002571321,0.0003000536,0.00006642597,0.0001037338,0.0008918957,0.000009763674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000774391,"about_ca_system_score_gemma":0.0001942678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001907087,"about_ca_topic_score_gemma":0.00007504436,"domain_scores_codex":[0.9980984,0.0005794339,0.0005362065,0.0001066215,0.000342192,0.0003370972],"domain_scores_gemma":[0.9971133,0.001300315,0.0005862919,0.0002541036,0.0006803956,0.00006557391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.05068554,0.001954807,0.004778409,0.000182882,0.006001766,0.0001395176,0.01237719,0.0009633854,0.8642336,0.005256656,0.04148869,0.01193754],"study_design_scores_gemma":[0.02812904,0.03660299,0.04272407,0.00305641,0.000806105,0.009851697,0.02621116,0.001250906,0.5712928,0.001200873,0.2780885,0.0007854144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.974115,0.001630153,0.0003694051,0.02274896,0.0002593599,0.0004329519,0.00001088078,0.000007588644,0.0004256871],"genre_scores_gemma":[0.9956643,0.002100809,0.0002788797,0.0007639683,0.00008424443,0.000009613235,0.000008486869,0.00001962871,0.001070093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2929408,"threshold_uncertainty_score":0.3874893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01632482589516064,"score_gpt":0.2770769793174212,"score_spread":0.2607521534222605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}