{"id":"W2164744416","doi":"10.4049/jimmunol.171.2.538","title":"Cutting Edge: The Conversion of Arginine to Citrulline Allows for a High-Affinity Peptide Interaction with the Rheumatoid Arthritis-Associated HLA-DRB1*0401 MHC Class II Molecule","year":2003,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":707,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Western University","funders":"","keywords":"Citrulline; Citrullination; Epitope; Arginine; Major histocompatibility complex; Chemistry; MHC class I; Peptide; MHC class II; Human leukocyte antigen; Autoimmunity; Rheumatoid arthritis; Immunology; Antigen; Biology; Immune system; Biochemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002137357,0.0002753641,0.0001965477,0.0001005079,0.0001018142,0.0003390195,0.0003079547,0.0004952512,0.002793823],"category_scores_gemma":[0.0001923711,0.0001195067,0.0001318744,0.00007589802,0.000246997,0.00025311,0.0002277943,0.0005508977,0.0008072736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001565462,"about_ca_system_score_gemma":0.00008264425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009190261,"about_ca_topic_score_gemma":0.0001113267,"domain_scores_codex":[0.9998404,0.00002791488,0.00001446452,0.00003985439,0.00004246448,0.00003498688],"domain_scores_gemma":[0.9998462,0.00004616639,0.0000458419,0.00002271465,0.00001222561,0.00002671004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009212829,0.00001838799,0.0001920353,0.00004664687,0.000002900376,0.00005377164,0.00000488823,0.00002167155,0.9969277,0.0001453263,0.00004948359,0.002445167],"study_design_scores_gemma":[0.00003542842,0.0005220402,0.003099413,0.00001092269,0.00001957103,0.001393034,0.00001505435,0.000270059,0.9885694,0.0001162876,0.00594461,0.000004102972],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868793,0.004414066,0.004542489,0.0003442202,0.00007880912,0.00002259414,0.0001348263,0.0001051992,0.003478572],"genre_scores_gemma":[0.9896785,0.001327073,0.005259211,0.0001891766,0.00004080625,0.00001341683,0.0002737749,0.00002734778,0.00319072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002793823,"threshold_uncertainty_score":0.009346247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01632482589516064,"score_gpt":0.2770769793174212,"score_spread":0.2607521534222605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}