{"id":"W2164754292","doi":"10.1002/jcb.20064","title":"Ryanodine receptor signaling is required for anti‐CD3‐induced T cell proliferation, interleukin‐2 synthesis, and interleukin‐2 receptor signaling","year":2004,"lang":"en","type":"article","venue":"Journal of Cellular Biochemistry","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Ryanodine receptor; Cell biology; Cell growth; T cell; Receptor; Signal transduction; Biology; Interleukin 2; Dantrolene; IL-2 receptor; Chemistry; Endocrinology; Intracellular; Internal medicine; Immunology; Biochemistry; Calcium; Immune system; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001015866,0.0003773465,0.0005598757,0.0001462394,0.0003104503,0.0001101972,0.00039669,0.0004635022,0.0005153817],"category_scores_gemma":[0.0002150583,0.0003479722,0.0003160224,0.000169906,0.0001654486,0.0002102351,0.00008496531,0.000725992,0.00001527955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002082543,"about_ca_system_score_gemma":0.0002753373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002819638,"about_ca_topic_score_gemma":2.922429e-7,"domain_scores_codex":[0.9978108,0.0001349276,0.000942378,0.0004011228,0.0002681167,0.0004426634],"domain_scores_gemma":[0.9978516,0.0002295576,0.0008715515,0.0001838315,0.0005224478,0.0003410794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006208876,0.0004132066,0.0005224891,0.0003071443,0.0002814313,0.00003119253,0.0005309593,0.00003498496,0.9932543,0.00001548576,0.003009592,0.0009783406],"study_design_scores_gemma":[0.002471972,0.0003093579,0.000008405854,0.0003228687,0.0002092775,0.00007707193,0.0004753004,0.00008757342,0.9868086,0.0001425774,0.008713322,0.0003736678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928051,0.001565843,0.002617497,0.001387158,0.001055648,0.0002981101,0.00008449608,0.00002720858,0.0001589214],"genre_scores_gemma":[0.9944391,0.0002659542,0.002985032,0.0006341865,0.001249816,0.00001833647,0.00003225858,0.00005130595,0.0003239939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006445681,"threshold_uncertainty_score":0.9998972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06814528733785223,"score_gpt":0.3551017791344543,"score_spread":0.2869564917966021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}