{"id":"W2164815481","doi":"10.1158/1078-0432.ccr-04-1676","title":"Phase I Trial and Pharmacokinetic Study of Raltitrexed in Children with Recurrent or Refractory Leukemia: A Pediatric Oncology Group Study","year":2005,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Cancer Institute","keywords":"Raltitrexed; Medicine; Pharmacokinetics; Refractory (planetary science); Dosing; Toxicity; Internal medicine; Pharmacology; Gastroenterology; Leukemia; Thymidylate synthase; Chemotherapy; Oncology; Fluorouracil","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007599522,0.001006129,0.001528741,0.0002075694,0.0001856763,0.0004054259,0.0006499878,0.0006949122,0.001390132],"category_scores_gemma":[0.0006343772,0.000244207,0.0007018533,0.0003512817,0.0006376693,0.0003146839,0.0001864496,0.001877264,0.0003636818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000944768,"about_ca_system_score_gemma":0.001446032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001231886,"about_ca_topic_score_gemma":0.002023163,"domain_scores_codex":[0.9996384,0.0001936715,0.00001785771,0.00005284383,0.00004734185,0.00004979662],"domain_scores_gemma":[0.9993721,0.00009944964,0.0001931207,0.00005633596,0.0000366252,0.0002425383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3734725,0.04439507,0.088904,0.002188398,0.003583015,0.003545127,0.001385365,0.01334213,0.1743396,0.0009619066,0.01037424,0.2835087],"study_design_scores_gemma":[0.2850285,0.601036,0.06508393,0.0001031689,0.001181491,0.004001119,0.0001378856,0.003123106,0.02640107,0.0002377759,0.01362246,0.00004349592],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945926,0.002645961,0.0005940418,0.000236931,0.00002450326,0.0006738853,0.0004847978,0.00005174641,0.000695545],"genre_scores_gemma":[0.989794,0.002796286,0.002845431,0.0004481091,0.0001063737,0.001294222,0.001756966,0.00003350581,0.0009250469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001528741,"threshold_uncertainty_score":0.006854773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1859500199093201,"score_gpt":0.5569707131992239,"score_spread":0.3710206932899038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}