{"id":"W2164877636","doi":"10.1021/ol301506b","title":"Short Synthesis of Enantiopure <i>trans</i>-3-Arylpiperazine-2-carboxylic Acid Derivatives via Diaza-Cope Rearrangement","year":2012,"lang":"en","type":"article","venue":"Organic Letters","topic":"Synthesis and Biological Activity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Enantiopure drug; Sodium periodate; Piperazine; Trifluoromethanesulfonate; Carboxylic acid; Ethylenediamine; Ring (chemistry); Ruthenium; Chloride; Medicinal chemistry; Stereochemistry; Organic chemistry; Catalysis; Enantioselective synthesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001861775,0.0005473452,0.0003853624,0.000153014,0.0001495043,0.000208057,0.0003587363,0.000395879,0.001411786],"category_scores_gemma":[0.0001545909,0.0002944685,0.0003464255,0.0001952989,0.0001467184,0.0002458256,0.0002738509,0.0006659666,0.00116078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001810383,"about_ca_system_score_gemma":0.0003197387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000272415,"about_ca_topic_score_gemma":0.0005067581,"domain_scores_codex":[0.9998456,0.00002034442,0.00001785795,0.00003266269,0.0000393626,0.00004417101],"domain_scores_gemma":[0.9998813,0.00001295627,0.00003192607,0.00001437325,0.00001843316,0.00004091881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005590417,0.00001478404,0.00005744298,0.00008036646,0.00001008667,0.0002488783,0.00001931552,0.0001921115,0.9953127,0.0002900852,0.0001376076,0.003580717],"study_design_scores_gemma":[0.00002088686,0.0002918519,0.0004333614,0.000003010844,0.00001415492,0.0005018624,0.000009113498,0.0004039754,0.9929441,0.00006721542,0.005296473,0.00001398222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8813533,0.005189662,0.08887498,0.0004333064,0.0003272457,0.0003233618,0.002712152,0.001175141,0.01961083],"genre_scores_gemma":[0.9492144,0.003219587,0.03824813,0.0001921562,0.00006243452,0.0001624878,0.001778778,0.0001598729,0.006962152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001411786,"threshold_uncertainty_score":0.004722953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01032023726620248,"score_gpt":0.2160438639748215,"score_spread":0.205723626708619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}