{"id":"W2164900051","doi":"10.1096/fj.05-4075fje","title":"Sphingosine kinase functionally links elevated transmural pressure and increased reactive oxygen species formation in resistance arteries","year":2006,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Sixth Framework Programme; Friedrich-Baur-Stiftung; Ludwig-Maximilians-Universität München","keywords":"NADPH oxidase; Reactive oxygen species; Vasoconstriction; RHOA; Cell biology; Sphingosine kinase; Chemistry; Sphingosine; Rho-associated protein kinase; Biochemistry; Signal transduction; Biology; Sphingosine-1-phosphate; Endocrinology; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003991179,0.0001213153,0.000190568,0.0001174342,0.0001738042,0.00005284566,0.00005446536,0.00008070456,0.00006159574],"category_scores_gemma":[0.0001033385,0.00007828961,0.00005161575,0.0001682415,0.00007720742,0.0002689885,0.000008334289,0.0005174852,0.000004128235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004737653,"about_ca_system_score_gemma":0.00005396133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000810105,"about_ca_topic_score_gemma":0.0001431178,"domain_scores_codex":[0.9990903,0.0001078183,0.0002715365,0.00009731155,0.0002447633,0.0001883204],"domain_scores_gemma":[0.9994549,0.0001406731,0.0001209148,0.0001087162,0.00009553865,0.00007926559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002867211,0.0001083301,0.005359906,0.00009546502,0.00006880672,0.000199682,0.0006556091,0.00004999922,0.9869051,0.000288008,0.002778766,0.0006231355],"study_design_scores_gemma":[0.00815348,0.0003867162,0.6792,0.0006194731,0.0004456422,0.002040701,0.0008828352,0.0007640266,0.2883298,0.003676644,0.01521274,0.0002878984],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931117,0.001335877,0.0003769983,0.003230356,0.00006890928,0.0002163871,0.00001633322,0.00002400622,0.001619477],"genre_scores_gemma":[0.9970626,0.0001081812,0.0002435015,0.0003228791,0.0004276129,0.000006276503,0.0000344131,0.00001183216,0.001782682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6985753,"threshold_uncertainty_score":0.3192557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01007857729520782,"score_gpt":0.2141086090143038,"score_spread":0.204030031719096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}