{"id":"W2164903312","doi":"10.1128/aac.45.10.2733-2739.2001","title":"Phase I/II Trial of the Pharmacokinetics, Safety, and Antiretroviral Activity of Tenofovir Disoproxil Fumarate in Human Immunodeficiency Virus-Infected Adults","year":2001,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":333,"is_retracted":false,"has_abstract":true,"ca_institutions":"Gilead Sciences (Canada)","funders":"National Institutes of Health; National Center for Research Resources; National Institute of Mental Health; Johns Hopkins University; University of Washington; Gilead Sciences","keywords":"Pharmacokinetics; Medicine; Placebo; Adverse effect; Dosing; Reverse-transcriptase inhibitor; Pharmacology; Discontinuation; Internal medicine; Virus; Gastroenterology; Sida; Virology; Viral disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00113141,0.001789008,0.001756007,0.0003655097,0.0003970662,0.0007044194,0.0006444864,0.001550524,0.003883523],"category_scores_gemma":[0.001502182,0.000579096,0.0008627192,0.0003140305,0.001160288,0.0008129865,0.0002216561,0.002584878,0.0008040188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006363586,"about_ca_system_score_gemma":0.0008421274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007889772,"about_ca_topic_score_gemma":0.001399507,"domain_scores_codex":[0.9996326,0.0001741216,0.00002002856,0.00006235491,0.00003448738,0.00007648398],"domain_scores_gemma":[0.9992208,0.0001632882,0.0001440873,0.00006476351,0.00004314061,0.0003638797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9155777,0.02656326,0.001679454,0.0003338493,0.0004849309,0.0001234051,0.0001383789,0.0005788392,0.01382623,0.000235019,0.001845082,0.03861391],"study_design_scores_gemma":[0.8258169,0.1685664,0.002396677,0.00001650025,0.000160103,0.00007959461,0.00002170116,0.0004663676,0.001486859,0.0001595208,0.0008176893,0.00001167511],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907199,0.002595204,0.0006750476,0.0006633979,0.0002163991,0.002447769,0.0007728896,0.0001209164,0.001788423],"genre_scores_gemma":[0.9900832,0.001668111,0.001557063,0.000870854,0.0002122975,0.002009381,0.001184142,0.0000241129,0.002390786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003883523,"threshold_uncertainty_score":0.01299167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01141155838644725,"score_gpt":0.2844821790997805,"score_spread":0.2730706207133333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}