{"id":"W2164903312","doi":"10.1128/aac.45.10.2733-2739.2001","title":"Phase I/II Trial of the Pharmacokinetics, Safety, and Antiretroviral Activity of Tenofovir Disoproxil Fumarate in Human Immunodeficiency Virus-Infected Adults","year":2001,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":333,"is_retracted":false,"has_abstract":true,"ca_institutions":"Gilead Sciences (Canada)","funders":"National Institutes of Health; National Center for Research Resources; National Institute of Mental Health; Johns Hopkins University; University of Washington; Gilead Sciences","keywords":"Pharmacokinetics; Medicine; Placebo; Adverse effect; Dosing; Reverse-transcriptase inhibitor; Pharmacology; Discontinuation; Internal medicine; Virus; Gastroenterology; Sida; Virology; Viral disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001302167,0.0002050429,0.0004374889,0.00009878861,0.0001332752,0.000009893709,0.00008447617,0.00007371046,0.00008045945],"category_scores_gemma":[0.000007099103,0.0001395777,0.00009250896,0.0002532369,0.0002053172,0.00006910742,0.00006760947,0.0001202462,5.777375e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002752459,"about_ca_system_score_gemma":0.00004329559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002307332,"about_ca_topic_score_gemma":0.00002502543,"domain_scores_codex":[0.9989389,0.00004613148,0.0003847798,0.0002552338,0.0001548343,0.0002201189],"domain_scores_gemma":[0.9995164,0.00001414682,0.0001947407,0.0001859267,0.00004390901,0.00004490634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.04741923,0.01105432,0.09042352,0.0001414181,0.0002440841,0.00001983368,0.002302361,7.821333e-7,0.7698993,0.00001834695,0.0005971612,0.07787965],"study_design_scores_gemma":[0.335844,0.004305596,0.1901,0.0004626561,0.0001881133,0.00003014985,0.00005762045,0.0002292372,0.463224,0.00001873542,0.005163785,0.0003760552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997593,0.00004772349,0.000007988462,0.00107957,0.00008414844,0.0008046601,0.00003235987,0.00001238928,0.0003381274],"genre_scores_gemma":[0.9956183,0.003005803,0.00003508329,0.0002347795,0.00003339167,0.000004099933,0.00002098153,0.00001877785,0.001028712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3066753,"threshold_uncertainty_score":0.5691815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01141155838644725,"score_gpt":0.2844821790997805,"score_spread":0.2730706207133333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}