{"id":"W2164908021","doi":"10.1021/ja037078a","title":"A Stereodivergent Approach to Chiral Nonracemic N-Protected α,α-Dialkylated Amino Acids","year":2003,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Chemistry; Curtius rearrangement; SN2 reaction; Reagent; Amino acid; Stereochemistry; Chiral auxiliary; Combinatorial chemistry; Cuprate; Enantioselective synthesis; Organic chemistry; Catalysis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002301861,0.000188351,0.0003681534,0.0000151345,0.00007539105,0.00002619289,0.0004882968,0.00009672892,0.00002030032],"category_scores_gemma":[0.0003160066,0.0001225988,0.000916478,0.0004293419,0.0001866747,0.000004057211,0.0001577619,0.0002839327,0.000003473822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007570345,"about_ca_system_score_gemma":0.0000583241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009888957,"about_ca_topic_score_gemma":2.141854e-7,"domain_scores_codex":[0.9986646,0.00009359958,0.0003883127,0.0002492419,0.0003106066,0.000293682],"domain_scores_gemma":[0.9988747,0.00001868715,0.0004375297,0.0003258549,0.0001380102,0.0002051746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006908718,0.0001574824,0.001292868,0.000005694508,0.0002507044,3.679494e-7,0.00006344492,0.00004402475,0.9925483,0.000004250827,0.004791868,0.0007719027],"study_design_scores_gemma":[0.0003637782,0.0001026949,0.000861577,0.0000130745,0.0001033812,0.00004359881,0.0001815283,0.00004526942,0.9844428,0.00003096005,0.01361445,0.0001968956],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976597,0.0001309319,0.001204904,0.000349378,0.00005744476,0.00009582547,0.000007391948,0.000005246929,0.0004891519],"genre_scores_gemma":[0.9894878,0.00006541158,0.008820917,0.001140337,0.0002386386,0.000005463868,0.000004273563,0.00001945408,0.0002176937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008822583,"threshold_uncertainty_score":0.4999433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009287929408351176,"score_gpt":0.2297323942661733,"score_spread":0.2204444648578221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}