{"id":"W2164908021","doi":"10.1021/ja037078a","title":"A Stereodivergent Approach to Chiral Nonracemic N-Protected α,α-Dialkylated Amino Acids","year":2003,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Chemistry; Curtius rearrangement; SN2 reaction; Reagent; Amino acid; Stereochemistry; Chiral auxiliary; Combinatorial chemistry; Cuprate; Enantioselective synthesis; Organic chemistry; Catalysis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002783219,0.0005098379,0.0002879034,0.0003259851,0.0002219744,0.0002909894,0.0007176566,0.0002665023,0.001438042],"category_scores_gemma":[0.0002426533,0.0001943291,0.0001698371,0.0002217075,0.0003681872,0.0004311376,0.0003537941,0.00076888,0.000594578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005223954,"about_ca_system_score_gemma":0.0005282084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006166961,"about_ca_topic_score_gemma":0.001019043,"domain_scores_codex":[0.9998611,0.00002079419,0.00001459602,0.00003542204,0.00003322617,0.00003480712],"domain_scores_gemma":[0.9998419,0.00001816312,0.00005037089,0.00003882077,0.00002101017,0.00002968922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000116722,0.00002914443,0.00005227554,0.00006515073,0.000004290588,0.000217311,0.00005581966,0.0002086269,0.9892778,0.003629208,0.0001444496,0.006199303],"study_design_scores_gemma":[0.00001921722,0.0002022561,0.0001961935,0.00000327149,0.000005156548,0.000304133,0.00000812187,0.0002855703,0.9946852,0.0001923642,0.004090753,0.000007886971],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9325468,0.001654639,0.04276618,0.0003685881,0.0001481694,0.0001648274,0.0005076806,0.0006783337,0.02116477],"genre_scores_gemma":[0.9776858,0.001221619,0.01520422,0.00008277616,0.00002903583,0.00005054686,0.000257035,0.00008247398,0.005386413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001438042,"threshold_uncertainty_score":0.00481075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009287929408351176,"score_gpt":0.2297323942661733,"score_spread":0.2204444648578221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}