{"id":"W2164909389","doi":"10.1021/tx0498861","title":"Detection of Covalent Adducts to Cytochrome P450 3A4 Using Liquid Chromatography Mass Spectrometry","year":2004,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada); TransCanada (Canada)","funders":"","keywords":"Adduct; Chemistry; Mass spectrometry; Chromatography; Cytochrome P450; Liquid chromatography–mass spectrometry; Organic chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007918231,0.0007680946,0.0003491277,0.001555158,0.0005493616,0.0005332166,0.000580309,0.001091941,0.001493418],"category_scores_gemma":[0.0009245441,0.00037023,0.0003235376,0.0007372325,0.0006373993,0.0005753483,0.000491492,0.0009976008,0.001567991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004738082,"about_ca_system_score_gemma":0.0005290504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001180994,"about_ca_topic_score_gemma":0.001593797,"domain_scores_codex":[0.9991837,0.0001835438,0.00003876337,0.0001431741,0.0003500225,0.0001007831],"domain_scores_gemma":[0.999418,0.0001963751,0.0001600972,0.00005681324,0.0001120769,0.00005652648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003795839,0.00005263631,0.0007780508,0.00003285476,0.00001486085,0.00009163746,0.0000149265,0.0001004438,0.9940866,0.0002058618,0.0001488007,0.004435473],"study_design_scores_gemma":[0.000009022349,0.0002952037,0.002476868,0.000005158932,0.00001756247,0.0003932434,0.00002305769,0.00166615,0.9920202,0.0002949499,0.002785727,0.00001289915],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6258022,0.008848547,0.3420598,0.001468481,0.0002934323,0.0005333673,0.0015567,0.004351388,0.01508627],"genre_scores_gemma":[0.7972934,0.007977147,0.1773846,0.001342933,0.0001665081,0.0005252847,0.001555792,0.0001595466,0.01359482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001555158,"threshold_uncertainty_score":0.004996002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2321713890054315,"score_gpt":0.509172604711702,"score_spread":0.2770012157062706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}