{"id":"W2164909389","doi":"10.1021/tx0498861","title":"Detection of Covalent Adducts to Cytochrome P450 3A4 Using Liquid Chromatography Mass Spectrometry","year":2004,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada); TransCanada (Canada)","funders":"","keywords":"Adduct; Chemistry; Mass spectrometry; Chromatography; Cytochrome P450; Liquid chromatography–mass spectrometry; Organic chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002474049,0.0002986919,0.0006064618,0.001436125,0.0001558755,0.00001644743,0.0007021778,0.0006937143,0.000618635],"category_scores_gemma":[0.0005470851,0.0003166889,0.0001706502,0.00235887,0.0007774438,0.00008632106,0.0003928019,0.001925771,0.0001354579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005733919,"about_ca_system_score_gemma":0.0004039642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005740944,"about_ca_topic_score_gemma":0.00001454029,"domain_scores_codex":[0.9957748,0.0007578776,0.0007261182,0.0007063674,0.0005895135,0.001445306],"domain_scores_gemma":[0.9978154,0.0006239675,0.0001271562,0.0003813619,0.0003135052,0.0007386529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001296954,0.0007893553,0.0001476406,0.0001160981,0.00009724258,0.0001233861,0.0002416103,0.001213326,0.9934391,0.0008503018,0.00006557828,0.001619342],"study_design_scores_gemma":[0.002633831,0.0006748033,0.0007578068,0.00003850548,0.00003964884,0.00005742313,0.00007671843,0.0003125139,0.9852978,0.003364765,0.006467404,0.000278796],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994109,0.001343116,0.0006931784,0.0009558137,0.0005509987,0.000888069,0.00004992158,0.00004889437,0.001360958],"genre_scores_gemma":[0.9957327,0.0004631947,0.002588025,0.0005911662,0.0004159182,0.0001339551,0.000008427673,0.00004609261,0.00002057347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00814138,"threshold_uncertainty_score":0.9999285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2321713890054315,"score_gpt":0.509172604711702,"score_spread":0.2770012157062706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}