{"id":"W2164953175","doi":"10.1053/plac.2002.0815","title":"Adriana and Luisa Castellucci Award Lecture 2001 Hypoxia Inducible Factor-1: Oxygen Regulation of Trophoblast Differentiation in Normal and Pre-eclamptic Pregnancies—A Review","year":2002,"lang":"en","type":"review","venue":"Placenta","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":209,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"","keywords":"Trophoblast; Placenta; Spiral artery; Intervillous space; Decidua; Biology; Placentation; Preeclampsia; Endocrinology; Hypoxia (environmental); Andrology; Internal medicine; Transcription factor; Cell biology; Pregnancy; Fetus; Chemistry; Gene; Medicine; Oxygen; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006015056,0.0005759792,0.0009935924,0.00154407,0.0002880849,0.0008867186,0.0006188057,0.0009331582,0.006182665],"category_scores_gemma":[0.0008210646,0.0002051144,0.0003015467,0.001706876,0.0002611814,0.0009784899,0.0005908152,0.001147416,0.002590752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005257136,"about_ca_system_score_gemma":0.001070742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001708054,"about_ca_topic_score_gemma":0.003101197,"domain_scores_codex":[0.9998641,0.00001906749,0.00001508144,0.00002206563,0.00006371865,0.00001580431],"domain_scores_gemma":[0.9997409,0.00009986392,0.00002594648,0.000004862513,0.00009620823,0.00003220738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001839619,0.00005385975,0.000339896,0.00805114,0.0000441939,0.0003668164,0.00007886413,0.0001109325,0.001636235,0.001362244,0.1179907,0.8697813],"study_design_scores_gemma":[0.00003150916,0.00009028289,0.001160796,0.001641486,0.00007052668,0.00109775,0.00005171642,0.00003006253,0.0004392769,0.0005107699,0.9948657,0.00001018195],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001310819,0.9953668,0.0001014981,0.001182638,0.001637806,0.000006317406,0.00001706477,0.000004828365,0.001551925],"genre_scores_gemma":[0.0006347019,0.9946235,0.0001586317,0.0004036163,0.001223826,0.000007442351,0.000025028,0.000001499083,0.002921697],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006182665,"threshold_uncertainty_score":0.02068311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04691709188904507,"score_gpt":0.2933142632577094,"score_spread":0.2463971713686643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}