{"id":"W2164963680","doi":"10.1161/circulationaha.113.006611","title":"Ryanodine Receptor–Mediated Calcium Leak Drives Progressive Development of an Atrial Fibrillation Substrate in a Transgenic Mouse Model","year":2014,"lang":"en","type":"article","venue":"Circulation","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":181,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Ryanodine receptor 2; Ryanodine receptor; Medicine; Internal medicine; Endocrinology; Atrial fibrillation; Genetically modified mouse; Receptor; Transgene; Biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001812501,0.0001137763,0.000272333,0.0001257789,0.00004585271,0.000004436575,0.00002623722,0.0001466644,0.00001576107],"category_scores_gemma":[0.00005796535,0.0001104047,0.00009611031,0.0001698945,0.00004600944,0.0001164987,0.000005179151,0.0001059473,0.000008729141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007332152,"about_ca_system_score_gemma":0.0001617207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004133532,"about_ca_topic_score_gemma":0.00001788749,"domain_scores_codex":[0.9990235,0.00008587422,0.0003496035,0.0002228248,0.0001497608,0.0001684344],"domain_scores_gemma":[0.9995418,0.00003584021,0.0001278125,0.0001426606,0.00009073166,0.00006117531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0008455755,0.00004131158,0.01697717,0.0000701971,0.00005964533,0.000001494003,0.001718967,0.1190638,0.8510616,0.0001404003,0.000002804468,0.01001702],"study_design_scores_gemma":[0.005050609,0.0002606718,0.396986,0.0001274447,0.00007928421,0.00001148109,0.00005913892,0.4051751,0.1915237,0.0003636517,0.00005322168,0.0003096194],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957724,0.0000608254,0.00341807,0.00005720573,0.00004957075,0.0005383088,0.000004119816,0.00004249679,0.00005695785],"genre_scores_gemma":[0.9978763,0.000005979689,0.001313231,0.00001320501,0.0002473927,0.0000129527,0.0005012068,0.00001571372,0.00001402692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6595379,"threshold_uncertainty_score":0.4502175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02183546784282052,"score_gpt":0.2763928404575926,"score_spread":0.2545573726147721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}