{"id":"W2164982699","doi":"10.1186/ar3173","title":"Perturbation of adhesion molecule-mediated chondrocyte-matrix interactions by 4-hydroxynonenal binding: implication in osteoarthritis pathogenesis","year":2010,"lang":"en","type":"article","venue":"Arthritis Research & Therapy","topic":"Biochemical effects in animals","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital du Sacré-Cœur de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Cell adhesion molecule; Integrin; Chemistry; Cell biology; Cell adhesion; Focal adhesion; Blot; Chondrocyte; Molecular biology; Kinase; Signal transduction; Biology; Cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00102546,0.0001943548,0.0003775457,0.0005433689,0.0001250736,0.00004043326,0.0002151004,0.0002682041,0.0005342839],"category_scores_gemma":[0.001044763,0.0001877303,0.0001248905,0.0009902889,0.0003086085,0.0002053638,0.00006405808,0.001027354,0.0001229328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001115307,"about_ca_system_score_gemma":0.0001592776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001651457,"about_ca_topic_score_gemma":0.0001019691,"domain_scores_codex":[0.9973502,0.0002971818,0.000539691,0.0004906105,0.0007962767,0.000526085],"domain_scores_gemma":[0.998014,0.000666451,0.0001192057,0.0005033807,0.0004443978,0.0002525937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005105427,0.0004255095,0.001431149,0.00002545657,0.00001576784,0.00001951573,0.0002257363,2.572104e-7,0.9191645,0.0001016524,0.001273411,0.0768065],"study_design_scores_gemma":[0.004094651,0.001448164,0.003928598,0.0003066676,0.000003737747,0.00009268518,0.0001146643,0.0002694931,0.9802913,0.0001914671,0.009079601,0.0001789607],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934378,0.003009258,0.00004131135,0.001457967,0.0001172193,0.001141247,0.00009073594,0.00006190099,0.0006426036],"genre_scores_gemma":[0.992195,0.005958069,0.0006432995,0.0000949515,0.0001187849,0.0002913534,0.0003481218,0.00004973225,0.000300765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07662754,"threshold_uncertainty_score":0.7655419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0253728722611083,"score_gpt":0.3593326842839742,"score_spread":0.3339598120228659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}