{"id":"W2165015386","doi":"10.1073/pnas.1110789109","title":"Aβ neurotoxicity depends on interactions between copper ions, prion protein, and <i>N</i> -methyl- <scp>d</scp> -aspartate receptors","year":2012,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":237,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences","keywords":"NMDA receptor; Neurotoxicity; Glycine; Receptor; Chemistry; Glutamate receptor; Biochemistry; Biophysics; Hippocampal formation; Calcium; Cell biology; Amino acid; Biology; Neuroscience; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008134779,0.0001015752,0.0001051274,0.00007809555,0.0002223425,0.000022979,0.0003298318,0.00007932461,0.000003835057],"category_scores_gemma":[0.0009579824,0.00007359739,0.00006762584,0.0002375258,0.0003004898,0.00005325742,0.0001712985,0.0001400442,0.000001366606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001140273,"about_ca_system_score_gemma":0.00002200946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003146773,"about_ca_topic_score_gemma":6.98331e-8,"domain_scores_codex":[0.99892,0.00001762776,0.000214404,0.0002187105,0.0004471683,0.0001820523],"domain_scores_gemma":[0.9994408,0.00006975883,0.0002803013,0.00001293937,0.0001139102,0.00008225616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009948576,0.00004367558,0.04925689,0.00002996087,0.00001597367,1.303775e-9,0.00004819186,0.00001215574,0.9456665,0.001523816,0.001564882,0.001827996],"study_design_scores_gemma":[0.000116757,0.000093738,0.07194033,0.00005873212,0.00001205173,0.000002650431,0.00007560226,0.00001757256,0.9143319,0.001434865,0.0118681,0.00004765851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969506,0.0006368543,0.000002157809,0.0007062088,0.00002803626,0.0002858309,0.00001862091,0.000006031817,0.001365638],"genre_scores_gemma":[0.9986543,0.0001891487,0.0005021211,0.0002619244,0.0001788154,0.0000294007,9.175246e-7,0.000005575371,0.000177812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03133456,"threshold_uncertainty_score":0.3001215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03390944457048702,"score_gpt":0.3097826648111675,"score_spread":0.2758732202406805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}