{"id":"W2165019590","doi":"10.1038/ng.568","title":"New loci associated with kidney function and chronic kidney disease","year":2010,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":810,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"National Institute of Dental and Craniofacial Research; National Center for Research Resources; National Institute of General Medical Sciences; National Human Genome Research Institute; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute on Aging","keywords":"Biology; Kidney disease; Renal function; Cystatin C; Genome-wide association study; Creatinine; Population; Genetics; Kidney; Internal medicine; Endocrinology; Bioinformatics; Genotype; Single-nucleotide polymorphism; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007086833,0.0013319,0.0008984092,0.002267192,0.0008370493,0.001262724,0.001242071,0.002279826,0.006272607],"category_scores_gemma":[0.003031669,0.000505672,0.001281214,0.002073411,0.0007631395,0.0005498077,0.0008452318,0.00139393,0.0004717718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000428374,"about_ca_system_score_gemma":0.0003626891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001749557,"about_ca_topic_score_gemma":0.002143125,"domain_scores_codex":[0.9989142,0.0002546998,0.000120166,0.0003165156,0.00026202,0.000132377],"domain_scores_gemma":[0.9972727,0.001177193,0.0007063535,0.0001958856,0.0001998175,0.0004480275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008796755,0.0008962277,0.6024503,0.0005312273,0.003654125,0.06100049,0.002233703,0.003358838,0.2344566,0.01252223,0.005510628,0.06458896],"study_design_scores_gemma":[0.000798679,0.0004888943,0.9111408,0.000155604,0.002134326,0.04395691,0.0006150055,0.003138964,0.01150491,0.01124065,0.01468175,0.00014349],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810367,0.003921639,0.005449977,0.002457164,0.000412016,0.00003372905,0.001051916,0.0001238652,0.005513081],"genre_scores_gemma":[0.9902449,0.001002282,0.004069776,0.0005303697,0.0006676064,0.00002306521,0.0005709001,0.00006462353,0.002826586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006272607,"threshold_uncertainty_score":0.02098399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004292497832546768,"score_gpt":0.2328513326514471,"score_spread":0.2285588348189003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}