{"id":"W2165031609","doi":"10.1002/chem.201500020","title":"A Surprising Substituent Effect Provides a Superior Boronic Acid Catalyst for Mild and Metal‐Free Direct Friedel–Crafts Alkylations and Prenylations of Neutral Arenes","year":2015,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Synthesis of Indole Derivatives","field":"Chemistry","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Winnipeg; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; American Chemical Society Petroleum Research Fund","keywords":"Friedel–Crafts reaction; Chemistry; Substituent; Catalysis; Allylic rearrangement; Commodity chemicals; Boronic acid; Organic chemistry; Combinatorial chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007737538,0.0003122518,0.0004378635,0.00004559525,0.0002878177,0.0001894763,0.0003300272,0.00006475237,0.00003470305],"category_scores_gemma":[0.001738756,0.0002824886,0.0001528403,0.00009576835,0.0002920414,0.0003048138,0.0001508952,0.0002619258,0.000001075888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007649578,"about_ca_system_score_gemma":0.0001580514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000892845,"about_ca_topic_score_gemma":0.00000749434,"domain_scores_codex":[0.9984213,0.0001130436,0.0005559951,0.0003632673,0.0002205037,0.0003259035],"domain_scores_gemma":[0.9983277,0.0003556132,0.0003621461,0.0004016902,0.000216134,0.000336758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002090257,0.00008229587,0.007933739,0.0005642376,0.0003227754,0.00003408053,0.001407938,0.00004308268,0.987147,0.000006878905,0.0002192016,0.002029735],"study_design_scores_gemma":[0.002283798,0.00007653415,0.002781379,0.0004799482,0.0003237952,0.0004872915,0.0006766631,0.0004593665,0.9910201,0.0000955506,0.0009625629,0.0003530431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926827,0.004143766,0.0002005645,0.0001416667,0.00004255562,0.0001485062,0.0001351536,0.00005331726,0.002451785],"genre_scores_gemma":[0.9974947,0.00006460645,0.001870418,0.000006911097,0.0002559204,0.00002118037,0.00004067793,0.00006286454,0.0001827213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00515236,"threshold_uncertainty_score":0.9999627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02909109542072879,"score_gpt":0.246429527259895,"score_spread":0.2173384318391662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}