{"id":"W2165039690","doi":"10.2174/1574888x113086660068","title":"Immunogenicity and Tumorigenicity of Pluripotent Stem Cells and their Derivatives: Genetic and Epigenetic Perspectives","year":2013,"lang":"en","type":"review","venue":"Current Stem Cell Research & Therapy","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Induced pluripotent stem cell; Reprogramming; Immunogenicity; Epigenetics; Biology; Immune system; Stem cell; Cell therapy; Major histocompatibility complex; Cancer research; Cell; Embryonic stem cell; Immunology; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001517034,0.0009327738,0.001720645,0.0004801295,0.0003810676,0.000192829,0.0008904387,0.0004875306,0.00003294236],"category_scores_gemma":[0.00001720678,0.0006937824,0.0003865723,0.0004367579,0.001514164,0.00001763782,0.001334502,0.001059946,0.00001549104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001189261,"about_ca_system_score_gemma":0.0005986698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005692942,"about_ca_topic_score_gemma":0.000004935225,"domain_scores_codex":[0.993085,0.002264221,0.0009594635,0.001755051,0.000782766,0.001153552],"domain_scores_gemma":[0.9968368,0.0004146135,0.0004404182,0.001164914,0.0006185092,0.0005247575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009453225,0.0003234763,0.00007725101,0.009272848,0.0004207561,0.00000459041,0.0009535223,0.000001018559,0.06549801,0.00001014473,0.0001444287,0.9231994],"study_design_scores_gemma":[0.001940086,0.00235929,0.0003240235,0.003718453,0.0001412049,0.00007886589,0.002935733,0.0000619955,0.1043478,0.00008231165,0.8824715,0.001538721],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.21577,0.7808439,0.0001033978,0.00001120343,0.00009844007,0.002955709,0.000161757,0.00001182718,0.00004378987],"genre_scores_gemma":[0.02993814,0.9686638,0.00007875367,0.000003268204,0.0001647686,0.0003962932,0.00004195575,0.0001354865,0.0005775315],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9216607,"threshold_uncertainty_score":0.9995514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09352986527709352,"score_gpt":0.3611080952048499,"score_spread":0.2675782299277564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}