{"id":"W2165109132","doi":"10.1128/aac.45.2.517-524.2001","title":"Pharmacokinetics, Safety, and Antiviral Effects of Hypericin, a Derivative of St. John's Wort Plant, in Patients with Chronic Hepatitis C Virus Infection","year":2001,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":153,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute","keywords":"Hypericin; Pharmacokinetics; Medicine; Dosing; Adverse effect; Pharmacology; Hypericum perforatum; Virus; Oral administration; Hepatitis C virus; Gastroenterology; Internal medicine; Virology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003993187,0.0003076492,0.0005255089,0.0001324468,0.0002099602,0.0003308885,0.0001186145,0.000305632,0.0004878645],"category_scores_gemma":[0.00146018,0.0001963589,0.0002515719,0.0001606628,0.0003615068,0.000343578,0.0001113903,0.0006563416,0.0001724752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00034724,"about_ca_system_score_gemma":0.0002898327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005112414,"about_ca_topic_score_gemma":0.0006420935,"domain_scores_codex":[0.9997492,0.0001365821,0.00001618818,0.00003260266,0.00003434599,0.00003099684],"domain_scores_gemma":[0.9993612,0.0002038628,0.0001819315,0.00004786219,0.00004591038,0.0001593033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.1459645,0.008662994,0.2512225,0.0005262214,0.0008095076,0.001619056,0.001092216,0.004534368,0.3377443,0.0002576102,0.002325068,0.2452417],"study_design_scores_gemma":[0.01183611,0.3292027,0.6019902,0.00007076838,0.0006789471,0.003623723,0.0003615843,0.005055965,0.04075134,0.0002423467,0.006110768,0.0000755151],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998133,0.0009742656,0.0002196545,0.00007886827,0.000008813797,0.00003006866,0.00006158261,0.00002522775,0.0004683955],"genre_scores_gemma":[0.9991252,0.0002455449,0.0002022886,0.00006977838,0.00002139753,0.00002022997,0.00009546882,0.000004697662,0.0002153229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005255089,"threshold_uncertainty_score":0.002519429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003892609591473978,"score_gpt":0.2040042298490642,"score_spread":0.2001116202575902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}