{"id":"W2165109132","doi":"10.1128/aac.45.2.517-524.2001","title":"Pharmacokinetics, Safety, and Antiviral Effects of Hypericin, a Derivative of St. John's Wort Plant, in Patients with Chronic Hepatitis C Virus Infection","year":2001,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":153,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute","keywords":"Hypericin; Pharmacokinetics; Medicine; Dosing; Adverse effect; Pharmacology; Hypericum perforatum; Virus; Oral administration; Hepatitis C virus; Gastroenterology; Internal medicine; Virology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005798679,0.0001917071,0.0003777578,0.000114382,0.00006443267,0.000007269483,0.00006374796,0.0001216486,0.00009676676],"category_scores_gemma":[0.000004976528,0.0001591913,0.00003544378,0.0001486217,0.0001943118,0.00009658909,0.00003960463,0.0001306425,0.000001630053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002399512,"about_ca_system_score_gemma":0.0000212516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001530205,"about_ca_topic_score_gemma":0.0003290531,"domain_scores_codex":[0.9991716,0.00006348823,0.0002757753,0.0002292776,0.00003590421,0.0002240275],"domain_scores_gemma":[0.9996245,0.00003174504,0.0001801506,0.0001065758,0.00004338231,0.00001365997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001048737,0.0004117537,0.5772894,0.00008866305,0.0001769863,0.000003639939,0.0003360423,0.000002122532,0.4058082,0.00001750309,0.0003112036,0.01450571],"study_design_scores_gemma":[0.005811062,0.0008090694,0.6621797,0.0001599883,0.00002556208,0.000005816241,0.000003155302,0.000004953914,0.3270012,0.000006174323,0.003854757,0.0001385814],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99883,0.000207631,0.0001902392,0.00004306683,0.0001694744,0.0004183388,0.00008830231,0.00001177612,0.00004119142],"genre_scores_gemma":[0.9821723,0.01728405,0.00005608029,0.0002944749,0.00001251661,0.00000372871,0.0000885023,0.00001997419,0.0000683973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08489032,"threshold_uncertainty_score":0.6491634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003892609591473978,"score_gpt":0.2040042298490642,"score_spread":0.2001116202575902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}