{"id":"W2165111016","doi":"10.1084/jem.20062662","title":"Activation-induced cytidine deaminase acts as a mutator in <i>BCR-ABL1</i>–transformed acute lymphoblastic leukemia cells","year":2007,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Deutsche Krebshilfe; Deutsche Forschungsgemeinschaft; Stem Cell Network; T.J. Martell Foundation","keywords":"Somatic hypermutation; Activation-induced (cytidine) deaminase; Cytidine deaminase; Biology; ABL; Molecular biology; breakpoint cluster region; Philadelphia chromosome; Imatinib mesylate; Cancer research; Tyrosine kinase; Imatinib; Gene; B cell; Chromosomal translocation; Antibody; Genetics; Myeloid leukemia; Signal transduction","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002342369,0.000420403,0.0008872055,0.0007116707,0.0001396643,0.00001543901,0.0004840872,0.0002034679,0.000462423],"category_scores_gemma":[0.0006564033,0.0002517343,0.0001548328,0.0009307291,0.0004343246,0.0003187132,0.00008566682,0.0008301644,0.00006126217],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004514611,"about_ca_system_score_gemma":0.001813328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004193386,"about_ca_topic_score_gemma":0.0000174558,"domain_scores_codex":[0.9956436,0.0001546425,0.001365853,0.0002627803,0.001749697,0.0008234175],"domain_scores_gemma":[0.9966481,0.001364894,0.0005153196,0.0004308684,0.0003186054,0.000722244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009255055,0.0003874831,0.00008849383,0.00004322191,0.0002594409,0.001958686,0.004983483,0.00001710804,0.9802738,0.00005404323,0.001580814,0.001098337],"study_design_scores_gemma":[0.01968702,0.005711815,0.001371919,0.001134462,0.0002947074,0.005296186,0.007930876,0.0002943963,0.9573296,0.00005563915,0.0006770438,0.0002163551],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910046,0.0006040545,0.0009943395,0.002702461,0.0005376918,0.0007412407,0.000002474983,0.00002601773,0.003387116],"genre_scores_gemma":[0.9960991,0.0002580277,0.0003724015,0.001899678,0.0009045606,0.000009135237,0.000008057829,0.00007222877,0.0003768555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02294425,"threshold_uncertainty_score":0.9999935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0179862136583246,"score_gpt":0.3244481864357462,"score_spread":0.3064619727774216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}