{"id":"W2165136213","doi":"10.18632/oncotarget.6129","title":"Targeting mitochondrial RNA polymerase in acute myeloid leukemia","year":2015,"lang":"en","type":"article","venue":"Oncotarget","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health; University Health Network; Princess Margaret Cancer Centre; University of Toronto","funders":"University of Toronto; Stem Cell Network; Natural Sciences and Engineering Research Council of Canada; Broad Institute","keywords":"Gene knockdown; Oxidative phosphorylation; Mitochondrion; Biology; Myeloid leukemia; Molecular biology; Cancer research; NRF1; Mitochondrial biogenesis; Cell biology; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001956953,0.0001979132,0.0002164648,0.00008086381,0.00004953008,0.00002300207,0.000196612,0.0002685264,0.0001367136],"category_scores_gemma":[0.0002164465,0.0001949502,0.00008648564,0.0001453816,0.0000561762,0.000007634128,0.0001087128,0.00018817,0.0001797168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007359537,"about_ca_system_score_gemma":0.0003232724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001104473,"about_ca_topic_score_gemma":0.0000699891,"domain_scores_codex":[0.9985788,0.0001394201,0.0003043071,0.0004450651,0.0001589934,0.000373451],"domain_scores_gemma":[0.999303,0.00001131069,0.00008563333,0.0003119024,0.00007044,0.0002177344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004833842,0.00004008438,0.004415293,0.000003187276,0.0000248113,0.00005293076,0.0001177425,0.0002524101,0.899077,0.00006132796,0.09522477,0.0002470651],"study_design_scores_gemma":[0.005209024,0.0008021699,0.0006044461,0.00001460399,0.00003439817,0.00008267868,0.000238557,0.000322099,0.2855618,0.0002688959,0.7062014,0.0006599491],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804051,0.001054434,0.003830479,0.0004290001,0.004133517,0.0002731192,0.00003719337,0.0000396921,0.009797482],"genre_scores_gemma":[0.9431599,0.0004122226,0.02113933,0.004451072,0.007450907,0.0001319965,0.001690411,0.0001326411,0.02143154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6135152,"threshold_uncertainty_score":0.7949837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01367802613558431,"score_gpt":0.2574121773066362,"score_spread":0.2437341511710519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}