{"id":"W2165136213","doi":"10.18632/oncotarget.6129","title":"Targeting mitochondrial RNA polymerase in acute myeloid leukemia","year":2015,"lang":"en","type":"article","venue":"Oncotarget","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health; University Health Network; Princess Margaret Cancer Centre; University of Toronto","funders":"University of Toronto; Stem Cell Network; Natural Sciences and Engineering Research Council of Canada; Broad Institute","keywords":"Gene knockdown; Oxidative phosphorylation; Mitochondrion; Biology; Myeloid leukemia; Molecular biology; Cancer research; NRF1; Mitochondrial biogenesis; Cell biology; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002612384,0.0002557493,0.0002490088,0.0002470837,0.0001686812,0.000387037,0.000252618,0.0003713631,0.001194679],"category_scores_gemma":[0.0001941643,0.0001441562,0.0001830668,0.0001694516,0.0002564572,0.0002103006,0.0003058002,0.0006596926,0.0007094804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004056904,"about_ca_system_score_gemma":0.000291722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002610758,"about_ca_topic_score_gemma":0.0006154851,"domain_scores_codex":[0.9998698,0.000020205,0.00001350778,0.00002242619,0.0000501562,0.00002387274],"domain_scores_gemma":[0.9999156,0.00001146847,0.00003392794,0.000005436199,0.00001545798,0.00001806405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008310389,0.0001909359,0.001807545,0.001270069,0.0000396943,0.0003979958,0.00007818354,0.0004931004,0.9108387,0.002016509,0.004699202,0.07733684],"study_design_scores_gemma":[0.0005946707,0.003240795,0.007839035,0.0003832914,0.0001867611,0.003450259,0.0002275893,0.00485771,0.7818411,0.001756161,0.1955914,0.00003126742],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6702132,0.265313,0.03281875,0.009332635,0.002581468,0.0007123323,0.0009720105,0.001244467,0.01681215],"genre_scores_gemma":[0.906993,0.07348791,0.008892274,0.0009976822,0.0002850763,0.0002915307,0.0006164893,0.00004035749,0.008395615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001194679,"threshold_uncertainty_score":0.003996611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01367802613558431,"score_gpt":0.2574121773066362,"score_spread":0.2437341511710519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}