{"id":"W2165145892","doi":"10.1186/gm344","title":"Pharmacogene regulatory elements: from discovery to applications","year":2012,"lang":"en","type":"article","venue":"Genome Medicine","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Liver Center, University of California, San Francisco; University of California, San Francisco; National Institutes of Health","keywords":"Computational biology; Chromatin immunoprecipitation; Enhancer; Pharmacogenomics; Chromatin; DNA sequencing; Biology; Massive parallel sequencing; Genetics; Gene; Promoter; Transcription factor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003250983,0.000881261,0.0009608736,0.001626333,0.0003205023,0.00297111,0.001405408,0.002488958,0.007615096],"category_scores_gemma":[0.005085578,0.0004696885,0.0005843739,0.002110679,0.001769376,0.002798483,0.001390306,0.002523914,0.003093832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001775371,"about_ca_system_score_gemma":0.001520453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008631891,"about_ca_topic_score_gemma":0.0007042912,"domain_scores_codex":[0.9990939,0.0002975384,0.0000634344,0.0001880529,0.0002821199,0.00007484565],"domain_scores_gemma":[0.9974353,0.001506306,0.0001581031,0.0002907013,0.0003851783,0.0002245098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002957672,0.00008853811,0.003403614,0.002451191,0.0001003451,0.0006083729,0.0002975173,0.003212921,0.01418262,0.1216192,0.03676961,0.8169702],"study_design_scores_gemma":[0.00006594109,0.000195089,0.00210366,0.001604607,0.0001043366,0.00122606,0.0003656046,0.005412104,0.01267168,0.1603437,0.8158466,0.00006070817],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01491952,0.6753108,0.1652446,0.08156583,0.003170843,0.0002963084,0.002574793,0.002433685,0.0544836],"genre_scores_gemma":[0.13049,0.6947132,0.1341618,0.01476705,0.003471984,0.0004564188,0.002788554,0.000427174,0.0187239],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007615096,"threshold_uncertainty_score":0.02547503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008180176494371352,"score_gpt":0.2579438825776704,"score_spread":0.2497637060832991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}