{"id":"W2165179743","doi":"10.1158/0008-5472.can-07-0392","title":"Phenethyl Isothiocyanate, a Cancer Chemopreventive Constituent of Cruciferous Vegetables, Inhibits Cap-Dependent Translation by Regulating the Level and Phosphorylation of 4E-BP1","year":2007,"lang":"en","type":"article","venue":"Cancer Research","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; McGill University","funders":"National Cancer Institute; U.S. Public Health Service; Hillman Foundation","keywords":"Phenethyl isothiocyanate; EIF4E; Cancer research; Phosphorylation; Apoptosis; Biology; Chemistry; Translation (biology); Cell biology; Biochemistry; Messenger RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008856643,0.0001264064,0.0001887191,0.00005113638,0.000109086,0.00001248216,0.0001682575,0.0001375951,0.00002591895],"category_scores_gemma":[0.00007556062,0.000107755,0.00005054743,0.0001556093,0.0004752856,0.000008083025,0.00009277536,0.0001922092,3.010115e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006497396,"about_ca_system_score_gemma":0.0002043772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001358891,"about_ca_topic_score_gemma":0.001046832,"domain_scores_codex":[0.9986126,0.00009412435,0.000340142,0.0003318341,0.0003175216,0.0003037073],"domain_scores_gemma":[0.9990451,0.00007339667,0.0001606248,0.0002244015,0.0004260406,0.00007038836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002594792,0.00004085739,0.002251461,0.0001036511,0.00007394489,3.693441e-7,0.0005261546,0.0001199985,0.9825128,0.00005180153,0.0003433169,0.01371622],"study_design_scores_gemma":[0.000719859,0.00006746073,0.001965609,0.0001026534,0.00001694063,0.000001649361,0.0003699871,0.00004187099,0.9955885,0.0002012779,0.0008145167,0.0001096058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9696311,0.02743566,0.001647844,0.0001253721,0.00006118516,0.0004463212,0.0001823722,0.000002656688,0.0004675291],"genre_scores_gemma":[0.9970624,0.002153393,0.0002140298,0.00002676278,0.0001036902,0.00005104662,0.00004965584,0.00001728356,0.0003217221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02743136,"threshold_uncertainty_score":0.439412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05684307266558901,"score_gpt":0.3540260973937283,"score_spread":0.2971830247281392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}