{"id":"W2165218854","doi":"10.1016/j.bmcl.2004.10.050","title":"Design and synthesis of (E)-1,1,2-triarylethenes: novel inhibitors of the cyclooxygenase-2 (COX-2) isozyme","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Isozyme; Cyclooxygenase; Selectivity; Stereochemistry; Enzyme inhibitor; Sulfone; Enzyme; Biochemistry; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002573227,0.0003675962,0.0002697707,0.0002257618,0.0001452901,0.0003090037,0.0004942274,0.000373037,0.001818929],"category_scores_gemma":[0.0001532591,0.0002435018,0.0002564244,0.0001882225,0.0001645004,0.0004844794,0.0002814273,0.0006076318,0.0006532653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002476606,"about_ca_system_score_gemma":0.0003078748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002037053,"about_ca_topic_score_gemma":0.0006483612,"domain_scores_codex":[0.9999135,0.00001159926,0.000009334427,0.00001799007,0.00002089105,0.00002682927],"domain_scores_gemma":[0.9999452,0.000005735564,0.00001551509,0.000005368574,0.0000106746,0.00001751992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003907102,0.0002941146,0.0001396634,0.0002207538,0.0000314678,0.0003517181,0.00009584575,0.002003198,0.9684877,0.003157689,0.0005846147,0.02424235],"study_design_scores_gemma":[0.0002662248,0.001348675,0.0004449842,0.0000159642,0.00004105151,0.0004418394,0.00002499262,0.002024675,0.9759564,0.0004457085,0.01896876,0.00002074879],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8729482,0.01273316,0.09734795,0.0009555274,0.0003537472,0.0007920354,0.0009976756,0.0004305308,0.01344115],"genre_scores_gemma":[0.9407256,0.00980264,0.03673437,0.0003081988,0.0000757195,0.0002805029,0.0009252187,0.00005840679,0.01108934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001818929,"threshold_uncertainty_score":0.006084919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009636012628210308,"score_gpt":0.207076345417756,"score_spread":0.1974403327895457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}