{"id":"W2165231572","doi":"10.1093/brain/awu309","title":"Reply: Parkinson’s disease in GTP cyclohydrolase 1 mutation carriers","year":2014,"lang":"en","type":"letter","venue":"Brain","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; National Institute for Health and Care Research; Wellcome Trust","keywords":"Disease; Mutation; GTP cyclohydrolase I; Parkinson's disease; Medicine; Neuroscience; Internal medicine; Genetics; Psychology; Biology; Gene; Tetrahydrobiopterin","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003806607,0.001300838,0.001863999,0.001116208,0.001719389,0.002478752,0.002495613,0.02632239,0.003751867],"category_scores_gemma":[0.03313205,0.0009248124,0.001307855,0.000791759,0.002415671,0.004694496,0.001715176,0.03238678,0.004487607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001353309,"about_ca_system_score_gemma":0.0014424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002701415,"about_ca_topic_score_gemma":0.002773848,"domain_scores_codex":[0.9976211,0.00064042,0.0005453606,0.000451155,0.0004709932,0.0002710033],"domain_scores_gemma":[0.9847194,0.007009917,0.00104874,0.0004818493,0.005330052,0.001409955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001853983,0.00004356138,0.002354411,0.0002849627,0.0000607311,0.003610475,0.0002999358,0.0000809093,0.0005665311,0.0007151783,0.9834252,0.00837282],"study_design_scores_gemma":[0.0002625421,0.0002795439,0.007627133,0.000982597,0.0002083511,0.03361041,0.001832427,0.0007857504,0.001412752,0.006008678,0.9465834,0.0004063506],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001042201,0.004553984,0.0002895417,0.9430593,0.05022101,0.00002127052,0.000216742,0.0001017032,0.0004941837],"genre_scores_gemma":[0.007087303,0.003561722,0.0005479137,0.9250302,0.06113638,0.00005386049,0.0001158948,0.000059734,0.002406944],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02632239,"threshold_uncertainty_score":0.02013147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006430510664613071,"score_gpt":0.229123252933038,"score_spread":0.2226927422684249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}