{"id":"W2165231572","doi":"10.1093/brain/awu309","title":"Reply: Parkinson’s disease in GTP cyclohydrolase 1 mutation carriers","year":2014,"lang":"en","type":"letter","venue":"Brain","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; National Institute for Health and Care Research; Wellcome Trust","keywords":"Disease; Mutation; GTP cyclohydrolase I; Parkinson's disease; Medicine; Neuroscience; Internal medicine; Genetics; Psychology; Biology; Gene; Tetrahydrobiopterin","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002634934,0.0003114852,0.0002686475,0.0001284805,0.00004187918,0.00003597426,0.000292036,0.0004676802,0.00006154177],"category_scores_gemma":[0.0003740259,0.0003276495,0.0001593228,0.00009890484,0.00008786343,0.000002203662,0.00006935559,0.0003518992,0.00004121957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007851841,"about_ca_system_score_gemma":0.0001653814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001424893,"about_ca_topic_score_gemma":0.0000545115,"domain_scores_codex":[0.9980775,0.0002519554,0.0003100524,0.000729641,0.0002320918,0.0003987676],"domain_scores_gemma":[0.998926,0.00002755877,0.0001410854,0.0007448361,0.00003297024,0.0001275257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004846575,0.00001569166,0.001179154,0.00007844604,0.00002762826,0.0001482412,0.00004031922,0.0001254936,0.0008380687,0.000004501579,0.9956105,0.00188347],"study_design_scores_gemma":[0.0006348157,0.00003740593,0.002222789,0.00002555852,0.00003159129,0.000005595163,0.000009804782,0.00008359425,0.0003727243,0.0002688323,0.9959182,0.0003891479],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.1718948,0.004889435,0.0008858747,0.8159543,0.001229253,0.001037399,0.0003294877,0.00005011009,0.003729362],"genre_scores_gemma":[0.06753261,0.0001754819,0.0001711844,0.9182311,0.002565131,0.0001415134,0.004848464,0.00009422602,0.006240315],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1043622,"threshold_uncertainty_score":0.9999176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006430510664613071,"score_gpt":0.229123252933038,"score_spread":0.2226927422684249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}