{"id":"W2165255765","doi":"10.1016/j.autrev.2013.08.002","title":"HLA shared epitope and ACPA: Just a marker or an active player?","year":2013,"lang":"en","type":"review","venue":"Autoimmunity Reviews","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"","keywords":"Epitope; Autoantibody; Immunology; Allele; Human leukocyte antigen; Antibody; Biology; Immune system; Antigen; Citrullination; Antigen presentation; Genetics; Gene; Citrulline; T cell; Arginine; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.002976354,0.001159271,0.007739416,0.0004761242,0.0002995742,0.000195152,0.0009945035,0.0008986489,0.004132367],"category_scores_gemma":[0.002220512,0.0006820065,0.00086789,0.0009422087,0.0002896268,0.0004534838,0.0007601872,0.002017425,0.00265108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005572163,"about_ca_system_score_gemma":0.001227049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002164929,"about_ca_topic_score_gemma":0.00004381311,"domain_scores_codex":[0.991878,0.003403957,0.002176333,0.0009922673,0.0006615186,0.0008879314],"domain_scores_gemma":[0.9938703,0.0009121032,0.001120636,0.00317095,0.0003072413,0.0006188274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005072009,0.0001308788,0.00002203293,0.125271,0.0003731613,0.00007655201,0.0005465049,1.941517e-9,0.000005650053,0.000008150163,0.01228775,0.8612276],"study_design_scores_gemma":[0.0006835565,0.0002779819,0.00004149062,0.1119601,0.001488675,0.01182527,0.0002537052,0.000008618603,6.664606e-7,0.000005481567,0.8728915,0.0005629282],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001875645,0.9839535,0.000004352096,0.00007673698,0.0002873258,0.01137215,0.0001112019,0.0001444096,0.003862724],"genre_scores_gemma":[0.000002237446,0.9763615,0.0008527152,0.0001520195,0.000304067,0.002446376,0.0006512594,0.0002256465,0.01900421],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8606647,"threshold_uncertainty_score":0.9995631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2729397089969223,"score_gpt":0.4488958411020552,"score_spread":0.1759561321051329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}