{"id":"W2165255765","doi":"10.1016/j.autrev.2013.08.002","title":"HLA shared epitope and ACPA: Just a marker or an active player?","year":2013,"lang":"en","type":"review","venue":"Autoimmunity Reviews","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"","keywords":"Epitope; Autoantibody; Immunology; Allele; Human leukocyte antigen; Antibody; Biology; Immune system; Antigen; Citrullination; Antigen presentation; Genetics; Gene; Citrulline; T cell; Arginine; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009684607,0.0009577797,0.002278178,0.001928878,0.0003033026,0.00164092,0.00109595,0.002000419,0.003384922],"category_scores_gemma":[0.00167394,0.0003403012,0.0005008395,0.002184477,0.0008685937,0.002115375,0.0009460313,0.00255666,0.001390283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007147173,"about_ca_system_score_gemma":0.001510312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001456774,"about_ca_topic_score_gemma":0.002475364,"domain_scores_codex":[0.9995977,0.00008396617,0.00006186856,0.00006584996,0.0001538085,0.00003673224],"domain_scores_gemma":[0.9991479,0.0004200526,0.0001527585,0.00001841913,0.0001758667,0.00008487407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001598185,0.00006879125,0.0005351297,0.01293532,0.0001531755,0.000375626,0.00005423071,0.000169024,0.0008366627,0.002434537,0.06825195,0.9140257],"study_design_scores_gemma":[0.00005962308,0.0001073044,0.001711213,0.007953794,0.0003714206,0.003216226,0.0001718992,0.0001144089,0.000221425,0.002933132,0.9831039,0.00003574474],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004130247,0.9990022,0.00004813929,0.0004316086,0.0002406035,0.00000107122,0.000005650983,0.000002543512,0.0002268505],"genre_scores_gemma":[0.0004715219,0.9981372,0.00009497324,0.0004895977,0.0005344406,0.000002256035,0.00001448048,7.252307e-7,0.0002547668],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003384922,"threshold_uncertainty_score":0.01132369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2729397089969223,"score_gpt":0.4488958411020552,"score_spread":0.1759561321051329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}