{"id":"W2165259537","doi":"10.1084/jem.20130783","title":"p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells","year":2013,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":401,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Istituto Pasteur-Fondazione Cenci Bolognetti","keywords":"NKG2D; CCL5; Lymphokine-activated killer cell; Chemokine; Biology; Senescence; Cancer research; Cell biology; Carcinogenesis; Natural killer cell; Interleukin 21; Immunology; T cell; In vitro; Immune system; Cytotoxicity; IL-2 receptor; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000207705,0.000255119,0.0002643754,0.0002251401,0.00009317365,0.0002663849,0.0001188085,0.000126416,0.0009373195],"category_scores_gemma":[0.0001861966,0.00009336576,0.0001922227,0.00009161772,0.0002120737,0.0001745881,0.0002714267,0.0003430321,0.0004437306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001965571,"about_ca_system_score_gemma":0.0001660947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003155861,"about_ca_topic_score_gemma":0.0004571137,"domain_scores_codex":[0.9997824,0.00005755843,0.00002547025,0.00002574528,0.00004987442,0.00005902592],"domain_scores_gemma":[0.9998367,0.00002658227,0.00003848777,0.00003462712,0.00002551257,0.00003808994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001837504,0.00003122874,0.000714077,0.00003389463,0.000002639874,0.00009777851,0.00002525842,0.00003936705,0.9974042,0.00008189818,0.00003796507,0.00134812],"study_design_scores_gemma":[0.00008871565,0.0007288742,0.02021967,0.0000152466,0.00002167653,0.0008405917,0.00007555511,0.002531785,0.9708412,0.0001555297,0.004472473,0.000008653498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966218,0.001197535,0.001166852,0.00004613378,0.00001551752,0.00001836389,0.0001374274,0.00003379213,0.0007625137],"genre_scores_gemma":[0.9980909,0.0003362764,0.0005486268,0.00001947624,0.00001067222,0.00001992864,0.0002811457,0.000007134294,0.0006858083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009373195,"threshold_uncertainty_score":0.003135622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005715317817607762,"score_gpt":0.2303378439837916,"score_spread":0.2246225261661839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}