{"id":"W2165262559","doi":"10.4049/jimmunol.1102930","title":"Beyond HLA-A*0201: New HLA-Transgenic Nonobese Diabetic Mouse Models of Type 1 Diabetes Identify the Insulin C-Peptide as a Rich Source of CD8+ T Cell Epitopes","year":2012,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Monique Weill-Caulier Trust; Canadian Institutes of Health Research; National Institute of Diabetes and Digestive and Kidney Diseases; Alberta Innovates; National Cancer Institute; National Institutes of Health; Canadian Diabetes Association","keywords":"Epitope; CD8; Human leukocyte antigen; Genetically modified mouse; Insulin; HLA-A; Transgene; Cytotoxic T cell; Immunology; Biology; Diabetes mellitus; Antigen; Endocrinology; Genetics; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004687314,0.001170053,0.0004758904,0.001097286,0.0002914637,0.0008732915,0.0005769553,0.001023355,0.002241609],"category_scores_gemma":[0.0001499009,0.000379263,0.0005419349,0.0005224484,0.0005157072,0.0006337168,0.0004218792,0.002611472,0.0009853997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002874164,"about_ca_system_score_gemma":0.0002868787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002558568,"about_ca_topic_score_gemma":0.0004393643,"domain_scores_codex":[0.9995037,0.00009532883,0.00006870031,0.0001304148,0.0001208468,0.0000809391],"domain_scores_gemma":[0.9996465,0.00004046227,0.00009244247,0.00004848748,0.00002854534,0.000143402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005668297,0.0003225376,0.0003608444,0.00008623603,0.00001163326,0.000161422,0.00004635601,0.00008670153,0.9940296,0.0006906028,0.000185986,0.003451333],"study_design_scores_gemma":[0.0005088013,0.003489158,0.007039359,0.0001148133,0.0001520334,0.002838063,0.0001413674,0.002521562,0.9432816,0.0009330421,0.03893565,0.00004458602],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.968802,0.005569216,0.01618372,0.001206474,0.0003592364,0.0002519066,0.002183784,0.0005557006,0.00488783],"genre_scores_gemma":[0.9242202,0.01229541,0.03622597,0.001029125,0.0002205389,0.0007869464,0.003506663,0.0003976205,0.0213174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002241609,"threshold_uncertainty_score":0.00749892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007515036886083358,"score_gpt":0.2241725546735693,"score_spread":0.216657517787486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}