{"id":"W2165322184","doi":"10.1128/mcb.23.21.7611-7627.2003","title":"Quantitative Analysis of CBP- and P300-Induced Histone Acetylations In Vivo Using Native Chromatin","year":2003,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research","keywords":"Biology; Histone Acetyltransferases; Histone; Acetylation; Chromatin; Histone H4; Histone methyltransferase; Histone-modifying enzymes; Histone H2A; Histone acetyltransferase; Histone code; P300-CBP Transcription Factors; Biochemistry; Histone H1; Molecular biology; Nucleosome; Cell biology; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002717806,0.0001362471,0.0002742516,0.0002459649,0.00004974447,0.000006882718,0.00004967298,0.000177331,0.00001388495],"category_scores_gemma":[0.0001292227,0.0001381146,0.00007364617,0.0003636141,0.0001274187,0.000003016091,0.00004196901,0.000061021,1.699765e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001268286,"about_ca_system_score_gemma":0.00003869901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001118999,"about_ca_topic_score_gemma":0.00008386523,"domain_scores_codex":[0.9989275,0.0002651369,0.0002623699,0.0003301246,0.00005486767,0.0001600212],"domain_scores_gemma":[0.9995518,0.00002764671,0.0001260996,0.0001727684,0.00007234461,0.00004928694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001580205,0.00003556959,0.01038414,0.000008423033,0.0002066134,0.000002247056,0.0001357674,0.0002962628,0.9848851,0.003886779,4.761457e-7,0.0001428033],"study_design_scores_gemma":[0.000382056,0.0002744118,0.002947299,0.000005323455,0.0001778868,0.000001225297,0.0001112968,0.002208446,0.9929373,0.0006172541,0.000178881,0.0001586641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9668034,0.005418578,0.02711972,0.00001750111,0.00003116684,0.0001315431,0.0000199157,0.000002559487,0.0004555692],"genre_scores_gemma":[0.9967317,0.000148354,0.002980309,0.00002396968,0.00000548984,0.000006425713,0.00006966787,0.00001114963,0.00002291063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02992827,"threshold_uncertainty_score":0.5632151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02045359549541508,"score_gpt":0.3112720881749048,"score_spread":0.2908184926794897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}