{"id":"W2165354935","doi":"10.1091/mbc.e05-07-0631","title":"Granule-mediated Killing by Granzyme B and Perforin Requires a Mannose 6-Phosphate Receptor and Is Augmented by Cell Surface Heparan Sulfate","year":2005,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; Howard Hughes Medical Institute","keywords":"Granzyme B; Mannose; Granzyme; Mannose 6-phosphate; Biology; Perforin; Heparan sulfate; Biochemistry; Cell biology; Cytotoxic T cell; Molecular biology; Receptor; Cell; Growth factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001836789,0.0004294896,0.0002757009,0.000174881,0.0001110749,0.0004645911,0.0001651935,0.000358929,0.000833349],"category_scores_gemma":[0.0002276744,0.0001590251,0.0002359884,0.0001305572,0.000310953,0.0004127072,0.0003594096,0.0003779217,0.0004280209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003512062,"about_ca_system_score_gemma":0.0001785937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002053835,"about_ca_topic_score_gemma":0.0001912718,"domain_scores_codex":[0.9997528,0.00005603111,0.00002330673,0.00003223545,0.00007949702,0.00005604655],"domain_scores_gemma":[0.9998648,0.00002585871,0.00004077631,0.00002761867,0.00001544698,0.00002541489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001006939,0.00001507358,0.0001437183,0.00001857543,0.000003014277,0.00005908445,0.000009799012,0.00005048207,0.9982896,0.0001385004,0.00001251508,0.001159007],"study_design_scores_gemma":[0.00003365199,0.0003098637,0.005196,0.000005766463,0.00001018593,0.0007053858,0.00003098641,0.001315817,0.9905995,0.0001851232,0.001602034,0.000005726621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956821,0.0009363205,0.002558524,0.00004097325,0.00001142194,0.00001229806,0.00004429373,0.00004579309,0.0006683009],"genre_scores_gemma":[0.9968747,0.0005596478,0.001333108,0.00001944342,0.000006173508,0.00001669176,0.0001435951,0.00001155283,0.001035056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000833349,"threshold_uncertainty_score":0.002787888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003809657247342263,"score_gpt":0.2050009570686455,"score_spread":0.2011912998213033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}