{"id":"W2165354935","doi":"10.1091/mbc.e05-07-0631","title":"Granule-mediated Killing by Granzyme B and Perforin Requires a Mannose 6-Phosphate Receptor and Is Augmented by Cell Surface Heparan Sulfate","year":2005,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; Howard Hughes Medical Institute","keywords":"Granzyme B; Mannose; Granzyme; Mannose 6-phosphate; Biology; Perforin; Heparan sulfate; Biochemistry; Cell biology; Cytotoxic T cell; Molecular biology; Receptor; Cell; Growth factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002290066,0.0002487317,0.0003055719,0.00004829024,0.0002076359,0.00001160738,0.0001946105,0.0003287937,0.0004154098],"category_scores_gemma":[0.00001907637,0.0001923354,0.00009819966,0.0001001699,0.0004105682,0.00006481375,0.0001206612,0.000316075,0.0001183086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002532298,"about_ca_system_score_gemma":0.00001363614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001759114,"about_ca_topic_score_gemma":0.000003304324,"domain_scores_codex":[0.9985569,0.000319393,0.0003613624,0.0003908424,0.00003209998,0.0003393817],"domain_scores_gemma":[0.9993267,0.00007342978,0.0002309714,0.0002801484,0.00005621188,0.00003255668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002696678,0.0001146254,0.001095706,0.00002347788,0.00007168833,3.689923e-7,0.0002231231,0.000004351721,0.9651588,0.00001180558,0.03264496,0.0003814774],"study_design_scores_gemma":[0.001476294,0.0002064806,0.00005884467,0.00001645533,0.00004305432,0.000009403705,0.00007792558,0.00006256234,0.8132234,0.000014239,0.1846465,0.0001648082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9669487,0.02988998,0.0002915344,0.001290783,0.0008159758,0.0002601508,0.00007008792,0.0000354992,0.0003972205],"genre_scores_gemma":[0.9813747,0.002358629,0.00009580659,0.0007344797,0.000008123217,0.000007163153,0.0003428625,0.00002322533,0.01505497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1520016,"threshold_uncertainty_score":0.784321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003809657247342263,"score_gpt":0.2050009570686455,"score_spread":0.2011912998213033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}