{"id":"W2165398525","doi":"10.1093/toxsci/kfi077","title":"Ah Receptor-Mediated Impairment of Interrenal Steroidogenesis Involves StAR Protein and P450scc Gene Attenuation in Rainbow Trout","year":2005,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Reproductive biology and impacts on aquatic species","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Internal medicine; Endocrinology; Cholesterol side-chain cleavage enzyme; Steroidogenic acute regulatory protein; Aryl hydrocarbon receptor; Cytochrome P450; Glucocorticoid receptor; Biology; Receptor; Chemistry; Glucocorticoid; Gene expression; Metabolism; Medicine; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007370912,0.0001131341,0.000164283,0.00006042896,0.00006509614,0.00001603578,0.0001686796,0.0001250258,0.00009074055],"category_scores_gemma":[0.000495874,0.00007513004,0.00003317498,0.0001508152,0.0007539734,0.00001428261,0.00009637896,0.00005454736,0.000004816339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002369905,"about_ca_system_score_gemma":0.00005169359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001461926,"about_ca_topic_score_gemma":0.00007174684,"domain_scores_codex":[0.9988588,0.0001677006,0.0002515497,0.0003755495,0.0001294211,0.0002169403],"domain_scores_gemma":[0.9996491,0.00003533357,0.0001114422,0.0001091224,0.00003640013,0.00005856517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009088231,0.0001472169,0.03055201,0.000003776452,0.00001009466,2.461155e-7,0.0001184431,0.00002008544,0.9650286,0.0000450282,0.00008846726,0.003895182],"study_design_scores_gemma":[0.0004441603,0.002417778,0.2512263,0.00001382963,0.000003265782,0.000003194627,0.0003714584,0.0001074334,0.7438627,0.0001286557,0.001284106,0.0001371415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974762,0.0008475768,0.00004490179,0.00115625,0.00003880323,0.0002925402,0.000009625668,0.000006810923,0.0001272923],"genre_scores_gemma":[0.9970502,0.0001573775,0.0023435,0.0001836476,0.0001014418,0.00002808058,0.00001606383,0.000002646433,0.0001170751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2211659,"threshold_uncertainty_score":0.3063714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02868437110325658,"score_gpt":0.2784487471572145,"score_spread":0.2497643760539579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}