{"id":"W2165398525","doi":"10.1093/toxsci/kfi077","title":"Ah Receptor-Mediated Impairment of Interrenal Steroidogenesis Involves StAR Protein and P450scc Gene Attenuation in Rainbow Trout","year":2005,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Reproductive biology and impacts on aquatic species","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Internal medicine; Endocrinology; Cholesterol side-chain cleavage enzyme; Steroidogenic acute regulatory protein; Aryl hydrocarbon receptor; Cytochrome P450; Glucocorticoid receptor; Biology; Receptor; Chemistry; Glucocorticoid; Gene expression; Metabolism; Medicine; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001216089,0.0003005997,0.0002811685,0.000306791,0.0002491575,0.0002273755,0.0001435911,0.0002106359,0.001288347],"category_scores_gemma":[0.0001373824,0.0001762015,0.0004733462,0.0001304531,0.000407317,0.0002430597,0.0002439131,0.0006230007,0.0002438008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005682302,"about_ca_system_score_gemma":0.0005026782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00448921,"about_ca_topic_score_gemma":0.00738093,"domain_scores_codex":[0.9998509,0.00001487651,0.000013538,0.00003991433,0.00004426017,0.00003652803],"domain_scores_gemma":[0.999866,0.000008852286,0.00004316348,0.00001512138,0.00002081592,0.00004596644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004141288,0.00002543592,0.001675426,0.0000212458,0.000009845355,0.00007937866,0.00003705888,0.00003628056,0.9969818,0.00004169456,0.00002111026,0.0006566447],"study_design_scores_gemma":[0.00009099243,0.002881479,0.1319276,0.000007803311,0.0001096317,0.0004751508,0.0003399223,0.0009138727,0.8605402,0.0001680604,0.002519415,0.00002588728],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998437,0.0002852768,0.0006701062,0.00006203463,0.00001470844,0.0000122295,0.0001732603,0.00002861693,0.0003167716],"genre_scores_gemma":[0.9956194,0.0003524152,0.0007338648,0.00005678529,0.000007258202,0.00004009237,0.0003780629,0.00001400017,0.002798208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00448921,"threshold_uncertainty_score":0.008926153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02868437110325658,"score_gpt":0.2784487471572145,"score_spread":0.2497643760539579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}