{"id":"W2165404127","doi":"10.1210/en.2013-1791","title":"Quantification of Binding of IGF-1 to BI 836845, a Candidate Therapeutic Antibody Against IGF-1 and IGF-2, and Effects of This Antibody on IGF-1:IGFBP-3 Complexes In Vitro and in Male C57BL/6 Mice","year":2014,"lang":"en","type":"article","venue":"Endocrinology","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Antibody; In vitro; Ligand (biochemistry); Internal medicine; Endocrinology; Receptor; Pharmacodynamics; Pharmacology; Biology; Medicine; Pharmacokinetics; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004214955,0.001036646,0.0003317676,0.001003249,0.0003090742,0.0003139219,0.0003626577,0.0006221522,0.001729917],"category_scores_gemma":[0.0001620566,0.0003476599,0.0004865676,0.0006231465,0.0003948454,0.0002400409,0.000203728,0.0011116,0.0005543156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005864626,"about_ca_system_score_gemma":0.0002499824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001978577,"about_ca_topic_score_gemma":0.003311719,"domain_scores_codex":[0.9993702,0.00009036619,0.00003994345,0.0001834569,0.0001958271,0.0001203139],"domain_scores_gemma":[0.9997069,0.00005012422,0.00009280556,0.00002645306,0.00003671264,0.00008693118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000946428,0.00002637272,0.000104476,0.00001601264,0.000005544052,0.000007098691,0.000009557854,0.00003023019,0.9993119,0.00002530934,0.00001565889,0.0003531577],"study_design_scores_gemma":[0.00001062299,0.0003142395,0.004617536,0.000003674838,0.00001703372,0.00006757711,0.00001662752,0.0008370802,0.9935212,0.00002170849,0.0005666956,0.00000604417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.957077,0.005125348,0.03210192,0.0001813329,0.0001303912,0.0001236712,0.001741916,0.0004531273,0.003065154],"genre_scores_gemma":[0.9452258,0.002595114,0.03505148,0.0002082677,0.00004036996,0.0002990903,0.002687825,0.0001269952,0.01376493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001978577,"threshold_uncertainty_score":0.005787134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01387954858665064,"score_gpt":0.2908917110938543,"score_spread":0.2770121625072036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}