{"id":"W2165413779","doi":"10.4049/jimmunol.175.7.4320","title":"TLR Signaling Tailors Innate Immune Responses in Human Microglia and Astrocytes","year":2005,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":730,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Microglia; TLR2; Proinflammatory cytokine; TLR3; Innate immune system; Cell biology; TLR4; Biology; Secretion; Toll-like receptor; Inflammation; Immunology; Signal transduction; Immune system; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002943933,0.0002391792,0.0002097321,0.000228835,0.0001559638,0.0003927283,0.00009060441,0.0003488864,0.001611996],"category_scores_gemma":[0.0002075905,0.0001632676,0.000330956,0.0001840971,0.0001295805,0.0001573123,0.0002363291,0.0003258882,0.001225646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001716889,"about_ca_system_score_gemma":0.0002622333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003905596,"about_ca_topic_score_gemma":0.0005171899,"domain_scores_codex":[0.9996946,0.00006971768,0.00002918859,0.00003845786,0.00006766645,0.0001004262],"domain_scores_gemma":[0.9999346,0.00001668707,0.0000142437,0.000009603146,0.00001487685,0.00001002984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006186641,0.00004707428,0.0008516925,0.00008354057,0.000006580456,0.0001813566,0.00004573273,0.00007532046,0.9951695,0.00007972743,0.0000941153,0.002746772],"study_design_scores_gemma":[0.0001597016,0.001402413,0.02776873,0.00008631095,0.0000820338,0.002590657,0.0003595961,0.001911993,0.9513022,0.000644549,0.01366471,0.00002711195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858446,0.006463467,0.002779978,0.0002014712,0.00005046787,0.00007853064,0.0007479499,0.0000546098,0.003779022],"genre_scores_gemma":[0.9911793,0.002770484,0.002300238,0.0001931429,0.00004830373,0.0001374832,0.001053155,0.00001502276,0.002302777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001611996,"threshold_uncertainty_score":0.00539273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01015782405682291,"score_gpt":0.2439804603811933,"score_spread":0.2338226363243704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}