{"id":"W2165424687","doi":"10.1158/1078-0432.ccr-05-2187","title":"Phosphatidylinositol 3′-Kinase/AKT Signaling Is Activated in Medulloblastoma Cell Proliferation and Is Associated with Reduced Expression of <i>PTEN</i>","year":2006,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"PTEN; Medulloblastoma; PI3K/AKT/mTOR pathway; Protein kinase B; Cancer research; Biology; Signal transduction; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001178234,0.000238041,0.0002106554,0.0003914945,0.0001428566,0.0002026907,0.0001307228,0.0001370505,0.0006724698],"category_scores_gemma":[0.000137485,0.0001224054,0.0001433264,0.0002986962,0.0002142879,0.0001017756,0.0001026915,0.0002779048,0.0001936636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002717304,"about_ca_system_score_gemma":0.0002235715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001907605,"about_ca_topic_score_gemma":0.001856538,"domain_scores_codex":[0.9998713,0.00001232492,0.00001253217,0.00002762493,0.00005131579,0.00002494044],"domain_scores_gemma":[0.9998926,0.00001322319,0.00005310196,0.000007234291,0.000009285709,0.00002454261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002157534,0.00002748826,0.007566861,0.00006009408,0.00001582453,0.0002502392,0.00001883123,0.00006091725,0.989698,0.00004075008,0.00004508133,0.002000067],"study_design_scores_gemma":[0.00003811794,0.0006352224,0.2821313,0.00001440219,0.00008606066,0.004516605,0.00007746446,0.001011656,0.7070468,0.00008236546,0.004352946,0.000007017903],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972108,0.001433356,0.0005568732,0.00002333111,0.000005322559,0.00001064029,0.0002102508,0.00004078774,0.0005086521],"genre_scores_gemma":[0.9980778,0.0008116752,0.0003812758,0.000009545613,0.000003907963,0.00001196008,0.0003596765,0.000004270785,0.0003398263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001907605,"threshold_uncertainty_score":0.003792942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04973267562810274,"score_gpt":0.3933977106905625,"score_spread":0.3436650350624597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}