{"id":"W2165436668","doi":"10.2174/1874079001003010116","title":"Role of the BCA2 Ubiquitin E3 Ligase in Hormone Responsive Breast Cancer","year":2010,"lang":"en","type":"article","venue":"The Open Cancer Journal","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"National Cancer Institute; Canadian Breast Cancer Research Alliance","keywords":"Ubiquitin ligase; SUMO protein; Ubiquitin; Cell biology; Transcription factor; RNF4; Estrogen receptor; Zinc finger; Chemistry; Ring finger; Ubiquitin-conjugating enzyme; Transcription (linguistics); Biology; Biochemistry; Gene; Genetics; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002327006,0.0003207435,0.0002724381,0.000531139,0.0004783207,0.0006468333,0.0001808111,0.000395067,0.001972073],"category_scores_gemma":[0.0001610572,0.000112361,0.0002403423,0.0005209198,0.0002399553,0.0002499445,0.0002948461,0.0002958036,0.0008730157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008823814,"about_ca_system_score_gemma":0.000358532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002082787,"about_ca_topic_score_gemma":0.001645706,"domain_scores_codex":[0.9998419,0.00003280683,0.000008664713,0.0000410942,0.00004439187,0.00003106613],"domain_scores_gemma":[0.99992,0.000008940782,0.00001453545,0.000007049899,0.00001991458,0.00002957613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002254251,0.0003001245,0.07071628,0.0008569065,0.0003321673,0.002613229,0.0001431139,0.001958189,0.8136495,0.003073102,0.00528851,0.09881458],"study_design_scores_gemma":[0.0001085796,0.0005724741,0.4105533,0.0000980757,0.0002318981,0.01250209,0.0003648407,0.01050119,0.4100171,0.00276022,0.1522251,0.00006513541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.792134,0.1833298,0.0058956,0.00182881,0.0001703498,0.00007901058,0.001933417,0.0002755148,0.01435349],"genre_scores_gemma":[0.9757825,0.01324482,0.001854611,0.0002418182,0.00004043215,0.00002264321,0.00129204,0.00001240311,0.00750867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002082787,"threshold_uncertainty_score":0.006597281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01037267231685013,"score_gpt":0.2837320596292192,"score_spread":0.273359387312369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}