{"id":"W2165441042","doi":"10.1002/ijc.20807","title":"Farnesyltransferase inhibitor SCH‐66336 downregulates secretion of matrix proteinases and inhibits carcinoma cell migration","year":2004,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Matrix metalloproteinase; Angiogenesis; Plasmin; Urokinase receptor; Plasminogen activator; Farnesyltransferase inhibitor; Cancer research; Secretion; Cell migration; Matrix metalloproteinase inhibitor; Farnesyltransferase; Cell biology; Biology; Cell growth; Chemistry; Molecular biology; Cell; Endocrinology; Biochemistry; Enzyme; Prenylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007716988,0.0005402466,0.0003271168,0.0002743377,0.0001487385,0.0002266465,0.0001738892,0.0002857856,0.001635627],"category_scores_gemma":[0.00008233785,0.0002010772,0.0003282558,0.0002536122,0.0001599551,0.000138481,0.0001023901,0.0005971211,0.0006899438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002068147,"about_ca_system_score_gemma":0.0003520065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001619907,"about_ca_topic_score_gemma":0.001798672,"domain_scores_codex":[0.9999136,0.00001169632,0.00000790099,0.00001124906,0.00001848784,0.00003707224],"domain_scores_gemma":[0.9999386,0.0000122454,0.00001420568,0.000008347864,0.000007464474,0.00001912838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002477508,0.0001058647,0.0001070692,0.00003704121,0.00000652212,0.00004293193,0.0000118679,0.0000842753,0.9975714,0.00004613287,0.00007005229,0.001669171],"study_design_scores_gemma":[0.00004461455,0.001287272,0.003213789,0.000004313837,0.00001962833,0.0001721487,0.00001730372,0.0006382581,0.9931068,0.00001911172,0.00147236,0.00000443755],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950487,0.002006313,0.0007411658,0.00009604258,0.000032206,0.00003482226,0.0003455769,0.0001139168,0.001581024],"genre_scores_gemma":[0.9939547,0.001897285,0.0007913875,0.00004519955,0.00001242849,0.00002560064,0.0007151181,0.00001473714,0.00254362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001635627,"threshold_uncertainty_score":0.005471766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004899743713279131,"score_gpt":0.2546675523226474,"score_spread":0.2497678086093682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}