{"id":"W2165456654","doi":"10.1124/mol.108.045690","title":"(2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide (BiPS), a Matrix Metalloprotease Inhibitor, Is a Novel and Potent Activator of Hypoxia-Inducible Factors","year":2008,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôtel-Dieu de Québec","funders":"National Cancer Institute","keywords":"Hydroxylation; Inducer; Hypoxia-Inducible Factor 1; Transcription factor; Hypoxia-inducible factors; Cell biology; Chemistry; Protein subunit; Activator (genetics); Biochemistry; Biology; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000141345,0.0003735135,0.0002520711,0.0002022413,0.0001570945,0.00015779,0.0002790162,0.0001919756,0.001209063],"category_scores_gemma":[0.00007896699,0.000132392,0.0001236891,0.0001511125,0.0001605222,0.0001408447,0.000145567,0.0004173703,0.000548979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002268874,"about_ca_system_score_gemma":0.0002566986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006722205,"about_ca_topic_score_gemma":0.000946475,"domain_scores_codex":[0.9998968,0.00001688929,0.000004552081,0.00001398837,0.00002777208,0.00004006299],"domain_scores_gemma":[0.9999334,0.000007013853,0.00002564746,0.000003815541,0.00000765249,0.00002251538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003843564,0.00004208306,0.00008608637,0.00006484997,0.000006941278,0.0000987665,0.000006344146,0.0001133406,0.9933271,0.0001923144,0.0004854369,0.005192267],"study_design_scores_gemma":[0.0001999801,0.001360124,0.004920833,0.000007470995,0.0000226057,0.0008354106,0.00001745015,0.0009369231,0.978283,0.00008710784,0.01331349,0.00001543474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9421775,0.01878056,0.01970962,0.001267981,0.0003902949,0.0001061021,0.0009606195,0.0008573122,0.01574998],"genre_scores_gemma":[0.9808895,0.006242111,0.005439424,0.0002649864,0.0002287925,0.00007656554,0.001020534,0.00004247836,0.005795606],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001209063,"threshold_uncertainty_score":0.004044652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01734220418751612,"score_gpt":0.2702163517547168,"score_spread":0.2528741475672007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}