{"id":"W2165456654","doi":"10.1124/mol.108.045690","title":"(2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide (BiPS), a Matrix Metalloprotease Inhibitor, Is a Novel and Potent Activator of Hypoxia-Inducible Factors","year":2008,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôtel-Dieu de Québec","funders":"National Cancer Institute","keywords":"Hydroxylation; Inducer; Hypoxia-Inducible Factor 1; Transcription factor; Hypoxia-inducible factors; Cell biology; Chemistry; Protein subunit; Activator (genetics); Biochemistry; Biology; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002088212,0.0005245336,0.0006587428,0.0002116591,0.0001890644,0.00001637295,0.0003589996,0.0004027006,0.0001231284],"category_scores_gemma":[0.00008519596,0.0005131038,0.0003411851,0.0002797606,0.0004374876,0.00002153988,0.0003747743,0.0003133598,0.000008072148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004479918,"about_ca_system_score_gemma":0.0003676798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001810276,"about_ca_topic_score_gemma":0.00000573771,"domain_scores_codex":[0.9972579,0.0001476601,0.0005759366,0.000971888,0.0003766695,0.0006699195],"domain_scores_gemma":[0.9985288,0.00002662393,0.0003140132,0.0005402947,0.0002114536,0.0003788183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002947446,0.0004184764,0.0004564296,0.00007314475,0.0004431277,0.00002646525,0.0002418527,0.00005771891,0.9937921,0.00006657906,0.003451562,0.0006777995],"study_design_scores_gemma":[0.003146475,0.0003424,0.002094845,0.00001161101,0.0002447893,0.0001751706,0.00006633286,0.00008796462,0.8974071,0.00004936348,0.09588416,0.0004898093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98661,0.007598991,0.002915991,0.0003067817,0.001348148,0.0008136884,0.0001645735,0.00003774189,0.0002040891],"genre_scores_gemma":[0.9938852,0.001329667,0.001767314,0.001095308,0.0007537252,0.0001304089,0.0001055726,0.00009133854,0.0008414199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09638502,"threshold_uncertainty_score":0.9997321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01734220418751612,"score_gpt":0.2702163517547168,"score_spread":0.2528741475672007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}