{"id":"W2165456897","doi":"10.1021/jo201303x","title":"Synthesis of 2- and 2,3-Substituted Pyrazolo[1,5-<i>a</i>]pyridines: Scope and Mechanistic Considerations of a Domino Direct Alkynylation and Cyclization of <i>N</i>-Iminopyridinium Ylides Using Alkenyl Bromides, Alkenyl Iodides, and Alkynes","year":2011,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Catalytic C–H Functionalization Methods","field":"Chemistry","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Ylide; Tandem; Aryl; Combinatorial chemistry; Domino; Cascade reaction; Surface modification; Pyridine; Alkyl; Reactive intermediate; Catalysis; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009216178,0.0002519736,0.0006483149,0.00009294126,0.0001410925,0.00002775375,0.0001233883,0.0001711932,0.000434995],"category_scores_gemma":[0.002595079,0.0002132947,0.00006103024,0.0002045151,0.0005849818,0.0002263895,0.0001245668,0.0001652261,9.263743e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004631455,"about_ca_system_score_gemma":0.0002286198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007381371,"about_ca_topic_score_gemma":0.00001280592,"domain_scores_codex":[0.9981798,0.00007075478,0.001064617,0.0002242262,0.0003101249,0.0001504714],"domain_scores_gemma":[0.9961366,0.001533404,0.001440462,0.0002821973,0.0004899013,0.0001174228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002328469,0.00007091869,0.002217205,0.0009164306,0.0002152822,0.000003010996,0.0006593455,0.00004137916,0.99515,0.0001526006,0.00003373154,0.0003071971],"study_design_scores_gemma":[0.0008602369,0.00002686596,0.0009223662,0.0005316041,0.0009185324,0.0009095869,0.0006593295,0.001160267,0.9922642,0.001552136,0.0000150229,0.0001798499],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928268,0.003158397,0.003361862,0.00005609918,0.00004895374,0.00009961123,0.0000721816,0.0000127213,0.0003633507],"genre_scores_gemma":[0.9929938,0.001781715,0.005077772,0.00001407226,0.00006666168,0.000001878846,0.000009651393,0.00003145314,0.00002296014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002885849,"threshold_uncertainty_score":0.8697904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03741088432579089,"score_gpt":0.2523641964644648,"score_spread":0.214953312138674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}