{"id":"W2165466849","doi":"10.1210/en.2012-1781","title":"P21-Activated Protein Kinase 1 (Pak1) Mediates the Cross Talk between Insulin and β-Catenin on Proglucagon Gene Expression and Its Ablation Affects Glucose Homeostasis in Male C57BL/6 Mice","year":2012,"lang":"en","type":"article","venue":"Endocrinology","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Glucose homeostasis; Internal medicine; Endocrinology; Proglucagon; Insulin; PAK1; Biology; Homeostasis; Glucagon; Wnt signaling pathway; Signal transduction; Glucagon-like peptide-1; Cell biology; Insulin resistance; Diabetes mellitus; Type 2 diabetes; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002078924,0.001587247,0.0004821382,0.001264432,0.000471719,0.0006929262,0.000458065,0.0007286748,0.004962852],"category_scores_gemma":[0.0001272095,0.0007642217,0.0007104604,0.0003441459,0.0007771653,0.0005202747,0.0004226434,0.001962698,0.001273424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006047771,"about_ca_system_score_gemma":0.0003366298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008685411,"about_ca_topic_score_gemma":0.001194518,"domain_scores_codex":[0.9995894,0.00004540025,0.00003885155,0.0001248813,0.00009539802,0.00010611],"domain_scores_gemma":[0.9996025,0.00002118564,0.0001574288,0.00002422242,0.00001952277,0.0001751496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000325942,0.0000785958,0.0001568502,0.00003899738,0.00000648638,0.00009802874,0.00002116802,0.00004245679,0.9983121,0.0001569049,0.00004622229,0.0007161704],"study_design_scores_gemma":[0.0001282809,0.0007555738,0.01219058,0.00002684648,0.00005420015,0.0008019339,0.00006632639,0.001109663,0.9820617,0.0001267703,0.002664856,0.00001326123],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992444,0.00151683,0.002607782,0.0002841679,0.00005265343,0.00004967089,0.001166758,0.0002697652,0.001608389],"genre_scores_gemma":[0.976986,0.002240421,0.004015134,0.0001435036,0.00004335712,0.0002246155,0.001591503,0.0001790755,0.01457637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004962852,"threshold_uncertainty_score":0.0166024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02236451491757803,"score_gpt":0.2782414092790186,"score_spread":0.2558768943614406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}