{"id":"W2165478614","doi":"10.1093/hmg/ddr417","title":"ALS mutations in FUS cause neuronal dysfunction and death in Caenorhabditis elegans by a dominant gain-of-function mechanism","year":2011,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Occupational Cancer Research Centre; University of Toronto","funders":"Medical Research Council; Directorate for Biological Sciences; National Research Foundation; Canadian Institutes of Health Research; Alzheimer Society; Wellcome Trust; Biotechnology and Biological Sciences Research Council; Central Michigan University; Johns Hopkins University; Canada Research Chairs; Howard Hughes Medical Institute","keywords":"Mutant; Caenorhabditis elegans; Biology; Phenotype; Cytoplasm; Amyotrophic lateral sclerosis; Mutation; Loss function; Cell biology; Genetics; Gene; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001598622,0.0001416963,0.0002211567,0.0002352406,0.00004567351,0.00001091733,0.00006339883,0.0001130643,0.0001212905],"category_scores_gemma":[0.00003587382,0.0001406429,0.00003956034,0.0001970576,0.00006714593,0.00003694854,0.0000528395,0.000220992,0.000005540995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000809163,"about_ca_system_score_gemma":0.00005533866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000872572,"about_ca_topic_score_gemma":0.0003634238,"domain_scores_codex":[0.9986865,0.0001137854,0.0003324581,0.0002939824,0.0002954975,0.0002777792],"domain_scores_gemma":[0.9994974,0.00001731212,0.00006722601,0.0002278462,0.00007736382,0.0001128927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001282179,0.0002582134,0.01604471,0.00004695946,0.00003487086,0.0002036716,0.0006433135,0.00004242714,0.9788489,0.002837942,0.00003147215,0.0008792887],"study_design_scores_gemma":[0.002770812,0.001385664,0.8985826,0.00009133625,0.00009361156,0.00004232975,0.00007267493,0.0008935038,0.08975355,0.006066277,0.00006408716,0.0001835456],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995209,0.0002815495,0.003611899,0.00005406357,0.0000445623,0.0004664822,0.000008744074,0.00001108253,0.0003125842],"genre_scores_gemma":[0.9987924,0.0001574085,0.0006993745,0.0001126031,0.00001848582,0.00004787426,0.0000520124,0.0000314233,0.00008839824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8890954,"threshold_uncertainty_score":0.573525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04384123388264925,"score_gpt":0.2865203140864047,"score_spread":0.2426790802037555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}