{"id":"W2165481944","doi":"10.1073/pnas.1010026107","title":"Rigid amphipathic fusion inhibitors, small molecule antiviral compounds against enveloped viruses","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":156,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; McMaster University Medical Centre; University of Alberta","funders":"Canadian Institutes of Health Research; Dynasty Foundation; GlaxoSmithKline; Burroughs Wellcome Fund","keywords":"Viral envelope; Lipid bilayer fusion; Vesicle; Viral entry; Amphiphile; Biophysics; Membrane curvature; Cell biology; Fusion; Membrane; Infectivity; Biology; Cell fusion; Viral membrane; Chemistry; Biochemistry; Viral replication; Virology; Cell; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005558871,0.000108189,0.0001145084,0.00007449061,0.0001716949,0.00002264458,0.0005970765,0.0001585802,0.000003756366],"category_scores_gemma":[0.0002281151,0.0000717866,0.00008576253,0.0002658397,0.0006947494,0.00002102663,0.0001988898,0.0001918688,7.836454e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004801326,"about_ca_system_score_gemma":0.00005264516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004178479,"about_ca_topic_score_gemma":6.548269e-7,"domain_scores_codex":[0.9988526,0.000005800873,0.0002381295,0.0002546608,0.0005055303,0.000143302],"domain_scores_gemma":[0.9994781,0.00001335124,0.0002579023,0.00001404259,0.0002048151,0.00003176105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001478592,0.00002994248,0.006626812,0.00001838474,0.000005502191,5.273984e-9,0.00003052954,0.000001410597,0.9914542,0.001199639,0.000267279,0.0003514427],"study_design_scores_gemma":[0.0001712116,0.00004150299,0.02020265,0.00002142267,0.000008424671,0.000005152323,0.00002687345,0.00002147246,0.9774675,0.0004265114,0.001513488,0.00009381816],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954976,0.00002404108,3.558051e-7,0.0003882819,0.00008137822,0.0001156217,0.00001476545,0.000006038631,0.003871848],"genre_scores_gemma":[0.9983622,0.00002111308,0.0007476229,0.0004676173,0.0002870807,0.000004929197,0.000001243802,0.000005407549,0.0001027369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01398679,"threshold_uncertainty_score":0.2927372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02682133288983552,"score_gpt":0.2876626427496703,"score_spread":0.2608413098598348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}