{"id":"W2165483878","doi":"10.1095/biolreprod.109.076000","title":"Identification of Potentially Damaging Amino Acid Substitutions Leading to Human Male Infertility1","year":2009,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; University of Toronto","funders":"","keywords":"Biology; Nonsynonymous substitution; Azoospermia; Single-nucleotide polymorphism; Genetics; Male infertility; SNP; Gene; Infertility; Genotype; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002506755,0.0000760118,0.0001316656,0.00006162405,0.00007293742,0.000005209871,0.0001164023,0.00008924255,0.00002536386],"category_scores_gemma":[0.0001569815,0.00007583151,0.00006434588,0.00008391471,0.0001455532,0.00000651549,0.00002993887,0.00003996865,0.000004911346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005885009,"about_ca_system_score_gemma":0.0000203379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008190862,"about_ca_topic_score_gemma":0.000005097235,"domain_scores_codex":[0.9990917,0.00003909228,0.000390802,0.0003148987,0.00005811149,0.0001054229],"domain_scores_gemma":[0.9992874,0.00000315938,0.0001672004,0.0003291862,0.0001790579,0.00003402946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002604304,0.00008255678,0.004272112,0.00001020341,0.00001175556,1.663211e-7,0.00004275235,0.00002887223,0.9786868,0.001005507,0.0000675156,0.01576571],"study_design_scores_gemma":[0.0001276217,0.0004418405,0.06592018,0.000008366445,0.00001250097,0.00001191432,0.00009222043,0.000002671617,0.9303064,0.0006130635,0.002386426,0.00007681621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937777,0.0004103361,0.004380366,0.0004587873,0.0001649984,0.000111993,0.000007352166,0.000009834915,0.0006786477],"genre_scores_gemma":[0.997914,0.00005566055,0.0005227922,0.00004345002,0.0001479007,0.000004328736,0.00007247488,0.000003123028,0.001236341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06164807,"threshold_uncertainty_score":0.3092319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01808662067022211,"score_gpt":0.3026212754887542,"score_spread":0.2845346548185321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}