{"id":"W2165483878","doi":"10.1095/biolreprod.109.076000","title":"Identification of Potentially Damaging Amino Acid Substitutions Leading to Human Male Infertility1","year":2009,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; University of Toronto","funders":"","keywords":"Biology; Nonsynonymous substitution; Azoospermia; Single-nucleotide polymorphism; Genetics; Male infertility; SNP; Gene; Infertility; Genotype; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002221925,0.0004032112,0.0003454193,0.0005159092,0.0002467769,0.0002195504,0.0001973456,0.0003560197,0.00123771],"category_scores_gemma":[0.0007704143,0.0001292269,0.0002380537,0.0003301527,0.0002284256,0.00008549141,0.000159298,0.0002126938,0.0002826203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001189027,"about_ca_system_score_gemma":0.00009583583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000369043,"about_ca_topic_score_gemma":0.000614505,"domain_scores_codex":[0.9998703,0.00002454048,0.00001295572,0.00003897445,0.00003617676,0.0000169145],"domain_scores_gemma":[0.9996427,0.0001614934,0.0001131666,0.00002157378,0.00002508742,0.00003579163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001314277,0.0002083988,0.1977034,0.0003374109,0.0003056756,0.009464998,0.0003734269,0.0009944162,0.7571108,0.000435312,0.0007105986,0.03104127],"study_design_scores_gemma":[0.0001333448,0.001045475,0.7574334,0.00005254608,0.000447035,0.0285369,0.0001747813,0.003457136,0.2038002,0.0004315093,0.00444346,0.00004411358],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968843,0.0009786665,0.001373796,0.00005725792,0.00001559492,0.00001635573,0.0003646915,0.00002417107,0.0002852142],"genre_scores_gemma":[0.9971765,0.0003815214,0.001596992,0.0000969297,0.00001925148,0.00001357327,0.0004804662,0.00000680007,0.0002279575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00123771,"threshold_uncertainty_score":0.004140615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01808662067022211,"score_gpt":0.3026212754887542,"score_spread":0.2845346548185321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}