{"id":"W2165489841","doi":"10.1371/journal.ppat.1003778","title":"Signatures of Pleiotropy, Economy and Convergent Evolution in a Domain-Resolved Map of Human–Virus Protein–Protein Interaction Networks","year":2013,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Science Foundation","keywords":"Biology; Protein–protein interaction; Computational biology; Protein domain; Sequence motif; Plasma protein binding; Protein sequencing; Genetics; Protein structure; Peptide sequence; Gene; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001190094,0.0001407868,0.0002110582,0.00006312394,0.00003457362,0.00001245723,0.0001009043,0.0002031797,0.0000530174],"category_scores_gemma":[0.000008785021,0.0001351384,0.00006662902,0.00004413817,0.00008209587,0.00001033543,0.00009891643,0.0001274451,0.000003691527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002431433,"about_ca_system_score_gemma":0.00002631623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000108146,"about_ca_topic_score_gemma":0.00009203688,"domain_scores_codex":[0.9990885,0.00004931707,0.0004131733,0.000191393,0.00006217104,0.0001953976],"domain_scores_gemma":[0.9993841,0.000006408574,0.0002458221,0.0002253633,0.0000820863,0.00005623356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005676328,0.00009305553,0.0008271147,0.0001013109,0.0000547708,6.319313e-7,0.00008425304,0.0003590981,0.9970036,0.0007244687,0.0001553095,0.0005396024],"study_design_scores_gemma":[0.00360021,0.001986685,0.01621375,0.0005470701,0.00008692853,0.000007542643,0.0008763174,0.04510817,0.9187921,0.009087715,0.002676779,0.00101675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939489,0.000820934,0.004080091,0.00003976073,0.00004323946,0.0007659002,0.00001770039,0.000004678436,0.0002787894],"genre_scores_gemma":[0.998337,0.00002055075,0.00126237,0.00002975524,0.00008790405,0.0001022938,0.00007215556,0.00001422518,0.00007371503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07821154,"threshold_uncertainty_score":0.5510782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007225965348930011,"score_gpt":0.2068472894678535,"score_spread":0.1996213241189235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}