{"id":"W2165497333","doi":"10.1016/j.nbd.2010.05.021","title":"Motor uncoordination and neuropathology in a transgenic mouse model of Machado–Joseph disease lacking intranuclear inclusions and ataxin-3 cleavage products","year":2010,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":72,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Fundação para a Ciência e a Tecnologia","keywords":"Machado–Joseph disease; Genetically modified mouse; Transgene; Biology; Trinucleotide repeat expansion; Huntingtin Protein; Neurodegeneration; Neuropathology; Astrogliosis; Huntington's disease; Atrophy; Neuroscience; Huntingtin; Genetics; Spinocerebellar ataxia; Disease; Ataxia; Pathology; Gene; Medicine; Central nervous system; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002918889,0.0009413465,0.0005146857,0.001600472,0.0005602612,0.0004656337,0.0005326206,0.001479347,0.002263134],"category_scores_gemma":[0.0003073982,0.000603138,0.0003581697,0.0003299941,0.0010115,0.0007077651,0.0004060227,0.001705523,0.0004132436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006864883,"about_ca_system_score_gemma":0.000500546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003049039,"about_ca_topic_score_gemma":0.005163325,"domain_scores_codex":[0.9996839,0.00003454501,0.00004205962,0.00008183782,0.00009548614,0.00006226921],"domain_scores_gemma":[0.9992847,0.00007153274,0.0002671682,0.00005363342,0.00005801944,0.00026501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000928389,0.0003230479,0.0006035753,0.00004674073,0.00003601172,0.001344836,0.00007828712,0.0001758268,0.9948012,0.0005454926,0.0001942873,0.0009223114],"study_design_scores_gemma":[0.0006469574,0.002340129,0.04752757,0.00005785664,0.0004425799,0.01340158,0.000387268,0.00774028,0.9225191,0.001368076,0.003484202,0.0000843759],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960383,0.0004307446,0.001309344,0.0002438703,0.00004745023,0.00003187326,0.0003680587,0.0001177209,0.001412568],"genre_scores_gemma":[0.992111,0.000336512,0.001859989,0.0001161218,0.00001658494,0.00005891783,0.0003151716,0.00006998067,0.005115745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003049039,"threshold_uncertainty_score":0.007570922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0200927405669192,"score_gpt":0.2469152526638993,"score_spread":0.2268225120969801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}