{"id":"W2165556149","doi":"10.1093/hmg/ddu564","title":"Landscape of DNA methylation on the X chromosome reflects CpG density, functional chromatin state and X-chromosome inactivation","year":2014,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":278,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pacific Centre for Reproductive Medicine; Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; Child and Family Research Institute","keywords":"X-inactivation; Biology; Dosage compensation; X chromosome; DNA methylation; Chromatin; Genetics; Skewed X-inactivation; Gene; XIST; Heterochromatin; CpG site; Methylation; Molecular biology; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000413143,0.0002047583,0.0001779969,0.00008736571,0.0001703059,0.00003967499,0.0001309747,0.0001436791,0.00003828902],"category_scores_gemma":[0.0001321417,0.0001767828,0.00008684057,0.0001294511,0.0001106613,0.000004697502,0.0001062195,0.0001112959,0.0000072764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001549255,"about_ca_system_score_gemma":0.00003509547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005499602,"about_ca_topic_score_gemma":0.00001649263,"domain_scores_codex":[0.9985716,0.0002351638,0.0003169902,0.0003664596,0.0003114288,0.0001983365],"domain_scores_gemma":[0.9990136,0.00005195617,0.0002292643,0.0004604034,0.0001760094,0.00006878001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002652654,0.00004622509,0.0007108371,0.00002188776,0.00005308213,7.328853e-7,0.00005428386,0.001290184,0.9942251,0.002011593,0.00008029578,0.00147927],"study_design_scores_gemma":[0.0004455194,0.0006425897,0.04729999,0.00001935474,0.0000338533,0.000002537403,0.00001500712,0.0007120969,0.9425348,0.007239457,0.00085822,0.0001965654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854974,0.0005765157,0.01214018,0.0001150034,0.00007601846,0.0002486055,0.000007982808,0.000009577912,0.00132869],"genre_scores_gemma":[0.9988263,0.0001217188,0.0004149893,0.0001746522,0.0001395741,0.00002345117,0.0001578251,0.00003595548,0.0001054792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05169027,"threshold_uncertainty_score":0.7208993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01803584645332453,"score_gpt":0.255203962927,"score_spread":0.2371681164736754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}