{"id":"W2165556149","doi":"10.1093/hmg/ddu564","title":"Landscape of DNA methylation on the X chromosome reflects CpG density, functional chromatin state and X-chromosome inactivation","year":2014,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":278,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pacific Centre for Reproductive Medicine; Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; Child and Family Research Institute","keywords":"X-inactivation; Biology; Dosage compensation; X chromosome; DNA methylation; Chromatin; Genetics; Skewed X-inactivation; Gene; XIST; Heterochromatin; CpG site; Methylation; Molecular biology; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002260534,0.0001183366,0.0002026965,0.0004372069,0.0001259218,0.000331465,0.00009830533,0.0001384845,0.001278134],"category_scores_gemma":[0.0004214682,0.0001350225,0.0001071461,0.0003625747,0.0001781549,0.0001143719,0.0002056308,0.0001558016,0.0001874291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001427412,"about_ca_system_score_gemma":0.00008554956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001433287,"about_ca_topic_score_gemma":0.002417115,"domain_scores_codex":[0.9998351,0.00003435845,0.000008704392,0.0000658146,0.0000325164,0.00002345757],"domain_scores_gemma":[0.9998404,0.00004843837,0.00005130197,0.00001761251,0.00002175046,0.00002057849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002879005,0.00001646861,0.4066145,0.00006728633,0.0001072541,0.00004642985,0.0002245461,0.0003547486,0.5781558,0.0002195157,0.00009482525,0.01381087],"study_design_scores_gemma":[0.000002122785,0.00004774111,0.9794534,0.000002767562,0.00001728613,0.0001658331,0.0000636143,0.0006542568,0.01913221,0.0001429146,0.0003136983,0.000004044834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969268,0.000466432,0.001537784,0.00001825337,0.000001562213,0.000003978893,0.0004072729,0.00001462608,0.0006232688],"genre_scores_gemma":[0.9985643,0.000139122,0.0005774442,0.00001198841,0.000002435129,0.000004521365,0.0003082583,0.00000562634,0.0003863989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001433287,"threshold_uncertainty_score":0.004275799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01803584645332453,"score_gpt":0.255203962927,"score_spread":0.2371681164736754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}