{"id":"W2165577772","doi":"10.1093/hmg/ddt455","title":"Abnormal Ras signaling in Costello syndrome (CS) negatively regulates enamel formation","year":2013,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Dental and Craniofacial Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; National Cancer Institute; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Genentech","keywords":"Ameloblast; Biology; Costello syndrome; Cell biology; MAPK/ERK pathway; HRAS; Anti-apoptotic Ras signalling cascade; Signal transduction; Kinase; PI3K/AKT/mTOR pathway; Cancer research; Enamel paint; Mutation; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007486243,0.0006593796,0.0001912184,0.0007601616,0.000197167,0.0001978706,0.0001741752,0.0004101917,0.001569115],"category_scores_gemma":[0.0001528931,0.0001556513,0.0001899529,0.0002330734,0.0003837203,0.0001308607,0.0003016965,0.0003605002,0.0002571042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002311134,"about_ca_system_score_gemma":0.0001968399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000964243,"about_ca_topic_score_gemma":0.001491929,"domain_scores_codex":[0.9998953,0.00001445883,0.000008340215,0.00002413749,0.00004116712,0.00001655836],"domain_scores_gemma":[0.9999291,0.00001405051,0.00002921279,0.000004345979,0.000006784061,0.0000165259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002431415,0.00002930125,0.003162476,0.00008915212,0.00001539415,0.003350771,0.00003719644,0.0001465683,0.983807,0.0005286455,0.0002428479,0.008347604],"study_design_scores_gemma":[0.00009904739,0.0007357261,0.09957213,0.00004123585,0.000198948,0.06363202,0.0001406513,0.002100881,0.813152,0.0008802374,0.01941593,0.00003125111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923196,0.002637677,0.001804076,0.0001904718,0.00002236724,0.00002370558,0.0002652995,0.0001107476,0.002625959],"genre_scores_gemma":[0.9955754,0.001271393,0.001767264,0.0000488135,0.00001381755,0.00001369473,0.0001198047,0.00001622209,0.001173628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001569115,"threshold_uncertainty_score":0.005249262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009579644446792135,"score_gpt":0.232126600875947,"score_spread":0.2225469564291549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}