{"id":"W2165615022","doi":"10.1182/blood-2002-03-0823","title":"Therapeutic factor VIII levels and negligible toxicity in mouse and dog models of hemophilia A following gene therapy with high-capacity adenoviral vectors","year":2003,"lang":"en","type":"article","venue":"Blood","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Genetic enhancement; Medicine; Immunology; Factor IX; Antibody; Clotting factor; Proinflammatory cytokine; In vivo; Cytokine; Immune system; Pharmacology; Internal medicine; Inflammation; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005208118,0.0005189127,0.0007189178,0.0006015503,0.0001650606,0.0006669997,0.0003367579,0.0007875477,0.001535112],"category_scores_gemma":[0.0003471002,0.0002172128,0.000342838,0.0003240031,0.0006046027,0.000536609,0.0001537935,0.0009555689,0.0004691218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004665625,"about_ca_system_score_gemma":0.0003140889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005045326,"about_ca_topic_score_gemma":0.0004619382,"domain_scores_codex":[0.9995629,0.00009575187,0.00003298881,0.0001064589,0.0001236088,0.00007826436],"domain_scores_gemma":[0.9996356,0.00006408156,0.0001145984,0.00005789442,0.00004044535,0.00008737829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001888228,0.0006163502,0.0003947561,0.00009693595,0.00002958007,0.0002098362,0.00004314395,0.0002611036,0.9915064,0.0003438507,0.0002980566,0.004311783],"study_design_scores_gemma":[0.0002850661,0.01522003,0.003283411,0.00002105963,0.0000922999,0.001752738,0.0000388355,0.001660149,0.9729866,0.0001607168,0.004480185,0.0000188044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865565,0.003316005,0.006205209,0.0001500805,0.00008236919,0.0002233727,0.0008959106,0.0002688906,0.002301639],"genre_scores_gemma":[0.9870785,0.002375054,0.004074201,0.00009375106,0.00003525213,0.0003099714,0.00156792,0.00007257216,0.004392675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001535112,"threshold_uncertainty_score":0.005135477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03236398465264031,"score_gpt":0.2678900686769251,"score_spread":0.2355260840242848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}